CEP55

Centrosomal protein of 55 kDa (Cep55), is a protein that in humans is encoded by the CEP55 gene.[5][6]

CEP55
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEP55, C10orf3, CT111, URCC6, centrosomal protein 55, MARCH
External IDsOMIM: 610000 MGI: 1921357 HomoloGene: 10019 GeneCards: CEP55
Orthologs
SpeciesHumanMouse
Entrez

55165

74107

Ensembl

ENSG00000138180

ENSMUSG00000024989

UniProt

Q53EZ4

Q8BT07

RefSeq (mRNA)

NM_001127182
NM_018131

NM_001164362
NM_028293
NM_028760
NM_001360663

RefSeq (protein)

NP_001120654
NP_060601

NP_001157834
NP_082569
NP_083036
NP_001347592

Location (UCSC)Chr 10: 93.5 – 93.53 MbChr 19: 38.04 – 38.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cep55 is a mitotic phosphoprotein that plays a key role in cytokinesis, the final stage of cell division.[7] and cilia formation in neural stem cells.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000138180 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024989 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK (Oct 2005). "Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis". Dev Cell. 9 (4): 477–88. doi:10.1016/j.devcel.2005.09.003. PMID 16198290.
  6. "Entrez Gene: CEP55 centrosomal protein 55kDa".
  7. van der Horst A, Simmons J, Khanna KK (November 2009). "Cep55 stabilization is required for normal execution of cytokinesis". Cell Cycle. 8 (22): 3742–3749. doi:10.4161/cc.8.22.10047. PMID 19855176.
  8. Behnam Rashidieh; Belal Shohayeb; Amanda Louise Bain; Patrick R. J. Fortuna; Debottam Sinha; Andrew Burgess; Richard Mills; Rachael C. Adams; J. Alejandro Lopez; Peter Blumbergs; John Finnie; Murugan Kalimutho; Michael Piper; James Edward Hudson; Dominic C. H. Ng; Kum Kum Khanna (October 2021). "Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis". PLOS Genetics. 17 (10): e1009334. doi:10.1371/journal.pgen.1009334. PMC 8577787. PMID 34710087.

Further reading


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