SFI1

Sfi1 homolog, spindle assembly associated (yeast) is a protein that in humans is encoded by the SFI1 gene. [5] It localizes to the centriole, and its S. pombe ortholog has been shown to be involved in spindle pole body duplication.[6] SFI1 forms a complex with centrin 2.[7]

SFI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSFI1, PISD, PPP1R139, hSfi1p, SFI1 centrin binding protein
External IDsOMIM: 612765 MGI: 1926137 HomoloGene: 12707 GeneCards: SFI1
Orthologs
SpeciesHumanMouse
Entrez

9814

78887

Ensembl

ENSG00000198089

ENSMUSG00000023764

UniProt

A8K8P3

Q3UZY0

RefSeq (mRNA)

NM_001007467
NM_001258325
NM_001258326
NM_001258327
NM_014775

NM_030207
NM_001363222
NM_001363223
NM_001363224

RefSeq (protein)

NP_001007468
NP_001245254
NP_001245255
NP_001245256
NP_055590

NP_084483
NP_001350151
NP_001350152
NP_001350153

Location (UCSC)Chr 22: 31.49 – 31.62 MbChr 11: 3.08 – 3.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000198089 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023764 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Sfi1 homolog, spindle assembly associated (yeast)". Retrieved 2014-06-25.
  6. Elserafy M, Šarić M, Neuner A, Lin TC, Zhang W, Seybold C, Sivashanmugam L, Schiebel E (July 2014). "Molecular mechanisms that restrict yeast centrosome duplication to one event per cell cycle". Current Biology. 24 (13): 1456–66. doi:10.1016/j.cub.2014.05.032. PMID 24954044.
  7. Martinez-Sanz J, Kateb F, Assairi L, Blouquit Y, Bodenhausen G, Abergel D, Mouawad L, Craescu CT (January 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex". Journal of Molecular Biology. 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500.

Further reading

Rüthnick D, Vitale J, Neuner A, Schiebel E. The N-terminus of Sfi1 and yeast centrin Cdc31 provide the assembly site for a new spindle pole body. J Cell Biol. 2021 Mar 1;220(3):e202004196. doi: 10.1083/jcb.202004196. PMID: 33523111; PMCID: PMC7852455.

  • Overview of all the structural information available in the PDB for UniProt: A8K8P3 (Protein SFI1 homolog) at the PDBe-KB.
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