CP-809101

CP-809101
Clinical data
ATC code	None;
Identifiers
	IUPAC name 2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine;
CAS Number	479683-64-2 ;
PubChem CID	9901086;
ChemSpider	8076740 ;
UNII	A2EXW95647;
CompTox Dashboard (EPA)	DTXSID60197369 ;
Chemical and physical data
Formula	C15H17ClN4O
Molar mass	304.78 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C2CNCCN2c(n3)cncc3OCc(c1)cccc1Cl;
	InChI InChI=1S/C15H17ClN4O/c16-13-3-1-2-12(8-13)11-21-15-10-18-9-14(19-15)20-6-4-17-5-7-20/h1-3,8-10,17H,4-7,11H2 ; Key:PCWGGOVOEWHPMG-UHFFFAOYSA-N ;
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CP-809101 is a drug which acts as a potent and selective 5-HT_2C receptor agonist.[1] It had promising results in animal models of obesity and psychosis, but associated with genotoxicity which means that future use will be restricted to scientific research applications only.[2][3]

References

Strong PV, Greenwood BN, Fleshner M (May 2009). "The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats". Psychopharmacology. 203 (4): 665–75. doi:10.1007/s00213-008-1413-3. PMID 19037632. S2CID 24956531.
Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA (February 2007). "CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity". Neuropharmacology. 52 (2): 279–90. doi:10.1016/j.neuropharm.2006.07.024. PMID 16949622. S2CID 46489320.
Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K (June 2007). "Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation" (PDF). Drug Metabolism and Disposition. 35 (6): 848–58. doi:10.1124/dmd.106.013649. PMID 17344339. S2CID 29863246. Archived from the original (PDF) on 2019-02-25.

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[pmid19037632-1] Strong PV, Greenwood BN, Fleshner M (May 2009). "The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats". Psychopharmacology. 203 (4): 665–75. doi:10.1007/s00213-008-1413-3. PMID 19037632. S2CID 24956531.

[pmid16949622-2] Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA (February 2007). "CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity". Neuropharmacology. 52 (2): 279–90. doi:10.1016/j.neuropharm.2006.07.024. PMID 16949622. S2CID 46489320.

[pmid17344339-3] Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K (June 2007). "Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation" (PDF). Drug Metabolism and Disposition. 35 (6): 848–58. doi:10.1124/dmd.106.013649. PMID 17344339. S2CID 29863246. Archived from the original (PDF) on 2019-02-25.