CYP107 family

Cytochrome P450, family 107, also known as CYP107, is a cytochrome P450 monooxygenase family in bacteria,[1] found to be conserved and highly populated in Streptomyces and Bacillus species.[2] The first gene identified in this family is Cytochrome P450 eryF (CYP107A1) from Saccharopolyspora erythraea.[3] Many enzymes of this family are involved in the synthesis of macrolide antibiotics.[4] The members of this family are widely distributed in Alphaproteobacteria, cyanobacterial, Mycobacterium, Bacillota, and Streptomyces species, which may be due to horizontal gene transfer driven by selection pressure.[5]

The evolutionary divergence of the CYP superfamily collected in 1990, CYP107 is the seventh prokaryotic CYP family identified[1]

References
  1. Nebert, DW; Nelson, DR; Coon, MJ; Estabrook, RW; Feyereisen, R; Fujii-Kuriyama, Y; Gonzalez, FJ; Guengerich, FP; Gunsalus, IC; Johnson, EF (January 1991). "The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature". DNA and Cell Biology. 10 (1): 1–14. doi:10.1089/dna.1991.10.1. PMID 1991046.
  2. Mnguni, FC; Padayachee, T; Chen, W; Gront, D; Yu, JH; Nelson, DR; Syed, K (7 July 2020). "More P450s Are Involved in Secondary Metabolite Biosynthesis in Streptomyces Compared to Bacillus, Cyanobacteria, and Mycobacterium". International Journal of Molecular Sciences. 21 (13): 4814. doi:10.3390/ijms21134814. PMC 7369989. PMID 32646068.
  3. Weber, JM; Leung, JO; Swanson, SJ; Idler, KB; McAlpine, JB (5 April 1991). "An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea". Science. 252 (5002): 114–7. Bibcode:1991Sci...252..114W. doi:10.1126/science.2011746. PMID 2011746.
  4. Kim, V; Lim, YR; Lee, I; Lee, JH; Han, S; Pham, TV; Kim, H; Lee, R; Kang, LW; Kim, D (15 October 2020). "Structural insights into CYP107G1 from rapamycin-producing Streptomyces rapamycinicus". Archives of Biochemistry and Biophysics. 692: 108544. doi:10.1016/j.abb.2020.108544. PMID 32822639.
  5. Nzuza, N; Padayachee, T; Syed, PR; Kryś, JD; Chen, W; Gront, D; Nelson, DR; Syed, K (2021-05-24). "Ancient Bacterial Class Alphaproteobacteria Cytochrome P450 Monooxygenases Can Be Found in Other Bacterial Species". International Journal of Molecular Sciences. 22 (11): 5542. doi:10.3390/ijms22115542. PMC 8197338. PMID 34073951.


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