CYP305M2

CYP305M2 (formerly called LM16181) is a cytochrome P450 enzyme found in migratory locust (Locusta migratoria) that catalyzes the key step of biosynthesis of phenylacetonitrile (PAN).[1][2] PAN in turn is used as an aposematic chemical defense against predators.

Biosynthesis of phenylacetonitrile catalyzed by CYP305M2 and subsequent decomposition to benzaldehyde and cyanide
Identifiers
OrganismLocusta migratoria
SymbolCYP305M2
UniProtA0A410UD22
Other data
EC number1.14.-.-
Search for
StructuresSwiss-model
DomainsInterPro

References
  1. Wei J, Shao W, Cao M, Ge J, Yang P, Chen L, Wang X, Kang L (January 2019). "Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor". Science Advances. 5 (1): eaav5495. Bibcode:2019SciA....5.5495W. doi:10.1126/sciadv.aav5495. PMC 6357733. PMID 30746481.
  2. "Cytochrome P450 [Locusta migratoria]". NCBI Protein. National Center for Biotechnology Information, U.S. National Library of Medicine.


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