Chlorosibutramine

Chlorosibutramine is an analogue of the anorectic drug sibutramine, which has been sold as an ingredient in weight loss products sold as dietary supplements, first detected in South Korea in 2013.[1][2][3] It is illegal in South Korea.[4]

Chlorosibutramine
Identifiers
  • 1-(1-(3,4-dichlorophenyl)cyclobutyl)-N,N,3-trimethylbutan-1-amine
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H25Cl2N
Molar mass314.29 g·mol−1
3D model (JSmol)
  • CC(C)CC(C1(CCC1)C2=CC(=C(C=C2)Cl)Cl)N(C)C
  • InChI=1S/C17H25Cl2N/c1-12(2)10-16(20(3)4)17(8-5-9-17)13-6-7-14(18)15(19)11-13/h6-7,11-12,16H,5,8-10H2,1-4H3
  • Key:AYHHTXUMSBRQFM-UHFFFAOYSA-N

See also

References
  1. Kim JW, Kweon SJ, Park SK, Kim JY, Lee JH, Han KM, Cho S, Kim J, Han SY, Kim HJ, Kim WS (2013). "Isolation and identification of a sibutramine analogue adulterated in slimming dietary supplements". Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment. 30 (7): 1221–9. doi:10.1080/19440049.2013.793826. PMID 23799645. S2CID 28127025.
  2. Yun J, Shin KJ, Choi J, Jo CH (May 2018). "Isolation and structural characterization of a novel sibutramine analogue, chlorosipentramine, in a slimming dietary supplement, by using HPLC-PDA, LC-Q-TOF/MS, FT-IR, and NMR". Forensic Science International. 286: 199–207. doi:10.1016/j.forsciint.2018.03.021. PMID 29602147.
  3. Jeong D, Choe S, Lee S, Kim KM, Pyo J (January 2021). "Metabolic analysis of the illegal analogues of anti-obesity drugs using LC-Q-TOF-MS/MS". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1163: 122502. doi:10.1016/j.jchromb.2020.122502. PMID 33412503. S2CID 231195145.
  4. "Anti-obesity drugs and their analogues: Chlorosibutramine" (PDF). FAOLEX Database. Food and Agriculture Organization of the United Nations.
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