Desmethylcitalopram

Desmethylcitalopram is an active metabolite of the antidepressant drugs citalopram (racemic) and escitalopram (the S-enantiomer, which would be called desmethylescitalopram).[1][2] Like citalopram and escitalopram, desmethylcitalopram functions as a selective serotonin reuptake inhibitor (SSRI), and is responsible for some of its parents' therapeutic benefits.

Desmethylcitalopram
Skeletal formula of desmethylcitalopram
Space-filling model of the desmethylcitalopram molecule
Clinical data
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Pharmacokinetic data
Elimination half-life50 h
Identifiers
  • (RS/S)-1-[3-(Methylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.057.776
Chemical and physical data
FormulaC19H19FN2O
Molar mass310.372 g·mol−1
3D model (JSmol)
  • CNCCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
  • InChI=1S/C19H19FN2O/c1-22-10-2-9-19(16-4-6-17(20)7-5-16)18-8-3-14(12-21)11-15(18)13-23-19/h3-8,11,22H,2,9-10,13H2,1H3 ☒N
  • Key:PTJADDMMFYXMMG-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

See also

References
  1. "Desmethylcitalopram". Human Metabolome Database.
  2. Brøsen K, Naranjo CA (August 2001). "Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram". European Neuropsychopharmacology. 11 (4): 275–83. doi:10.1016/s0924-977x(01)00101-8. PMID 11532381. S2CID 11837037.


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