Interleukin 8 receptor, beta

Interleukin 8 receptor, beta is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and Drug classification-recommended name.[5]

CXCR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCXCR2, CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, Interleukin 8 receptor, beta, C-X-C motif chemokine receptor 2, WHIMS2
External IDsOMIM: 146928 MGI: 105303 HomoloGene: 10439 GeneCards: CXCR2
Orthologs
SpeciesHumanMouse
Entrez

3579

12765

Ensembl

ENSG00000180871

ENSMUSG00000026180

UniProt

P25025

P35343

RefSeq (mRNA)

NM_001168298
NM_001557

NM_009909

RefSeq (protein)

NP_001161770
NP_001548

NP_034039

Location (UCSC)Chr 2: 218.13 – 218.14 MbChr 1: 74.19 – 74.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system (Gi/o-coupled[6]). This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. In addition, it binds ligands CXCL2, CXCL3, and CXCL5.

The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. IL8RB, IL8RA, which encodes another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.[7]

Mutations in CXCR2 cause hematological traits.[8]

Senescence

Knock-down studies involving the chemokine receptor CXCR2 alleviates both replicative and oncogene-induced senescence (OIS) and diminishes the DNA-damage response. Also, ectopic expression of CXCR2 results in premature senescence via a p53-dependent mechanism.[9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000180871 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026180 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Morris SW, Nelson N, Valentine MB, Shapiro DN, Look AT, Kozlosky CJ, Beckmann MP, Cerretti DP (Nov 1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics. 14 (3): 685–91. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896.
  6. "Entry in: gpDB, database of GPCRs, G-proteins, Effectors and their interactions". Retrieved 3 October 2012.
  7. "Entrez Gene: IL8RB interleukin 8 receptor, beta".
  8. Auer PL, Teumer A, Schick U, O'Shaughnessy A, Lo KS, Chami N, Carlson C, de Denus S, Dubé MP, Haessler J, Jackson RD, Kooperberg C, Perreault LP, Nauck M, Peters U, Rioux JD, Schmidt F, Turcot V, Völker U, Völzke H, Greinacher A, Hsu L, Tardif JC, Diaz GA, Reiner AP, Lettre G (Jun 2014). "Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits". Nature Genetics. 46 (6): 629–34. doi:10.1038/ng.2962. PMC 4050975. PMID 24777453.
  9. Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J (Jun 2008). "Chemokine signaling via the CXCR2 receptor reinforces senescence". Cell. 133 (6): 1006–18. doi:10.1016/j.cell.2008.03.038. PMID 18555777. S2CID 6708172.

Further reading


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