Keratin 4

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.[5][6]

KRT4
Identifiers
AliasesKRT4, CK-4, CK4, CYK4, K4, WSN1, Keratin 4
External IDsOMIM: 123940 MGI: 96701 HomoloGene: 20523 GeneCards: KRT4
Orthologs
SpeciesHumanMouse
Entrez

3851

16682

Ensembl

ENSG00000170477

ENSMUSG00000059668

UniProt

P19013

P07744

RefSeq (mRNA)

NM_002272

NM_008475

RefSeq (protein)

NP_002263

NP_032501

Location (UCSC)Chr 12: 52.81 – 52.81 MbChr 15: 101.83 – 101.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin 4 is a type II cytokeratin. It is specifically found in differentiated layers of the mucosal and esophageal epithelia together with keratin 13. Mutations in the genes encoding this protein have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000170477 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059668 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Barletta C, Batticane N, Ragusa RM, Leube R, Peschle C, Romano V (1990). "Subchromosomal localization of two human cytokeratin genes (KRT4 and KRT15) by in situ hybridization". Cytogenet. Cell Genet. 54 (3–4): 148–50. doi:10.1159/000132979. PMID 1702379.
  6. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  7. Chao SC, Tsai YM, Yang MH, Lee JY (June 2003). "A novel mutation in the keratin 4 gene causing white sponge naevus". Br. J. Dermatol. 148 (6): 1125–8. doi:10.1046/j.1365-2133.2003.05337.x. PMID 12828738. S2CID 26905614.

Further reading


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