Kalyana Veedu

• Thirumurugan as Gopi Krishnan - Surya husband, Sivagami and Muthaiah's Son, Anushya, Ramya, Savitha brother also Kalaivani, Manmadhan (main lead) (2018–present)
• R. Sundarrajan as Kathiresan - Surya and Roja father, Manikkavasam friend (2018–present)
• T. S. B. K. Mouli as Manikkavasam - Gopi adopted father, Kathiresan friend, Selvarani adopted brother (2019–present)
• Spoorthy Gowda as Surya Gopikrishnan - Roja's elder sister, Gopi wife, Kathiresan and Selvarani daughter (main lead) (2018-2020)
  • Kannika Ravi (601-present) as Surya (Replaced Spoorthy) (2020-end)
• Anjana K R as Swetha Suman - Suman wife, Gopi's best friend, Prathiksha mother, Nandakumar sister (main lead) (2018–present)
• Pavithra / Sree Priya as Roja Selvanraja - Raja's wife, Surya's younger sister, Kathiresan and Selvarani daughter. (main antagonist) (2018–present)
• Gopi as Selvanraja " Raja", Roja's husband, Surya ex fiancée, Gopi's friend (2018–present)
• Benze as Anushya - Gopi Sister, Sivagami and muthaiah daughter, Savitha, Ramya sister, Archana mother, Raman ex-wife, Surya sister in law. (2018–present)
• Dona Shanker as Ramya Manohar - Anushya, Savitha sister, Sivagami and muthaiah daughter, Manohar wife, Kala daughter in law, Revathi sister in law. (2018–present)
• Ankitha Bhat as Savitha - Pichaimani wife, Mutthaiah and Sivagami daughter, Gopi sister; anushya, Ramya sister and Padmavathi's daughter in law (2018–present)
• Pop Suresh as Manohar, Periyaswamy and Kala son, Ramya husband, Revathi brother. (2018–present)
• Hema Srikanth as Kala, Periyaswamy's wife, Manohar & Revathi's mother, Ramya'mother-in-law, Sakunthala's sister. (2018–present)
• Sathya as Sumandan "Suman", Swetha husband, Prathiksha father, Nandakumar brother in law. (2019–present)
• Munish Raja as Samantham, Anushya husband, Kalaivani ex love interest. (2020–present)
• Ravi Raj as Pichaimani, Parvathy son, Padmavathi's brother, Savitha husband, Kannan and Gopi brother in law. (2018–present)
• Jeyanthi as Sivagami Mutthaiah, mutthaiah wife, Gopi mother: Anshaya, Ramya, Savitha mother, Mutthaiah wife, Periyaswamy sister, Kala sister in law (2018–present)

• Kalaivani
• Bhagyalakshmi as Selvarani, Manikam's wife
• Sampath as Nandhakumar, Swetha's brother, Gopi's friend
• Smaleen Monica as Sulochana, Swetha friend, Nandakumar Wife
• Aishwarya Ramsai as Archana Raman, Anushya and Raman's daughter
• Prathiksha as Prathiksha Suman, Swetha and Suman's daughter
• Jayaraman as Periyasamy, Kala's husband
• Seema as Revathi Periyasamy, Manoharan's sister
• Jeyashree as Sakunthala Perumal, Kala's younger sister, Perumal's wife
• Radhika as Kavitha, Suganthi's assistant
• Meenatchi as Parvathi Parthasarathy, Piachaimani's mother
• Arunadevi as Padmavathi Kannan, Pichaimani's sister
• as Kannan, Pichaimani's uncle, Padmavathi's husband
• Priya Rathnakumar as Pavithra Kannan, Pichaimani's niece, Padmavathi's daughter
• Bavithran as Jithu, a womaniser who desires Savitha. Died in serial
• Saranya as Kausalya, Kathiresan's neighbour
• Kannan as Shekar, Gopi's friend.
• Yuvan Pattison as Bharath, Roja's friend
• Muthu Kumara Swamy as Raman, Anushya ex-husband
• Geethanjali as Suganthi, Raman 2nd Wife
• Kartic Krishna as Singapore Subramani
• Palaniappan as Selvam

• Aishwarya as Revathi Periyasamy
• Geetha as Sakunthala Perumal
• Punitha as Pavithra Kannan
• Ishitha as Suganthi Raman
• Sangeetha as Selva Rani (flashback role)
• Arunkumar Padmanabhan as Balakondaya (flashback role)

In September 2019, there was a complaint against the content of Kalyana Veedu following which the telecaster Sun TV was fined Rs 250,000 by the Broadcast Content Complaints Council. This was in reference to one of the episodes aired in May where one of the female characters named Roja hires a criminal gang to sexually assault her own sister. She ordered the men to show no mercy on her during this preplanned assault. The gang instead of following through the plan, enact the same plan on Roja. The controversial episodes were telecast on May 14, 15 and June 28, 2019.[3]

The council, on examining the video clips based on the complaints, said in their order that the content violated the Indian Broadcasting Foundation (IBF) guidelines which bars content that glorifies violence, as well as incite or encourage viewers to obscene or indecent behaviour. A notice was issued to the channel and in their reply to the council, Sun TV and Thiru Pictures clarified and apologised to the council. The order stated that they consented to agree with their decision as well.[4]