Polyomaviridae

Polyomaviridae is a family of viruses whose natural hosts are primarily mammals and birds.[1][2] As of 2020, there are six recognized genera and 117 species, five of which are unassigned to a genus.[3] 14 species are known to infect humans, while others, such as Simian Virus 40, have been identified in humans to a lesser extent.[4][5] Most of these viruses are very common and typically asymptomatic in most human populations studied.[6][7] BK virus is associated with nephropathy in renal transplant and non-renal solid organ transplant patients,[8][9] JC virus with progressive multifocal leukoencephalopathy,[10] and Merkel cell virus with Merkel cell cancer.[11]

Polyomaviridae
Micrograph showing a polyomavirus infected cell—large (blue) cell below-center-left. Urine cytology specimen.
Virus classification Edit this classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Sepolyvirales
Family: Polyomaviridae
Genera
  • Alphapolyomavirus
  • Betapolyomavirus
  • Deltapolyomavirus
  • Epsilonpolyomavirus
  • Gammapolyomavirus
  • Zetapolyomavirus

Structure and genome
A rendering of an icosahedral viral capsid comprising 72 pentamers of murine polyomavirus VP1, colored such that areas of the surface closer to the interior center appear blue and areas further away appear red. Rendered from PDB: 1SIE​.

Polyomaviruses are non-enveloped double-stranded DNA viruses with circular genomes of around 5000 base pairs. The genome is packaged in a viral capsid of about 40-50 nanometers in diameter, which is icosahedral in shape (T=7 symmetry).[2][12] The capsid is composed of 72 pentameric capsomeres of a protein called VP1, which is capable of self-assembly into a closed icosahedron;[13] each pentamer of VP1 is associated with one molecule of one of the other two capsid proteins, VP2 or VP3.[5]

Genome structure of the WU virus, a human polyomavirus. The early region is shown on the left and contains the TAg (tumor antigen) proteins; the late region is on the right and contains the capsid proteins.[14]

The genome of a typical polyomavirus codes for between 5 and 9 proteins, divided into two transcriptional regions called the early and late regions due to the time during infection in which they are transcribed. Each region is transcribed by the host cell's RNA polymerase II as a single pre-messenger RNA containing multiple genes. The early region usually codes for two proteins, the small and large tumor antigens, produced by alternative splicing. The late region contains the three capsid structural proteins VP1, VP2, and VP3, produced by alternative translational start sites. Additional genes and other variations on this theme are present in some viruses: for example, rodent polyomaviruses have a third protein called middle tumor antigen in the early region, which is extremely efficient at inducing cellular transformation; SV40 has an additional capsid protein VP4; some examples have an additional regulatory protein called agnoprotein expressed from the late region. The genome also contains a non-coding control or regulatory region containing the early and late regions' promoters, transcriptional start sites, and the origin of replication.[2][12][5][15]

Replication and life cycle
Murine polyomavirus VP1 in complex with the GT1a glycan. GT1a is shown in yellow and the VP1 monomer with a white surface and a blue protein backbone. A complex network of hydrogen bonds, many water-mediated, is shown at the binding surface by orange lines, with participating protein residues shown as sticks. Mutations of the two residues shown in cyan at the bottom of the figure can significantly affect pathogenicity. From PDB: 5CPW​.[16]

The polyomavirus life cycle begins with entry into a host cell. Cellular receptors for polyomaviruses are sialic acid residues of glycans, commonly gangliosides. The attachment of polyomaviruses to host cells is mediated by the binding of VP1 to sialylated glycans on the cell surface.[2][12][15][16] In some particular viruses, additional cell-surface interactions occur; for example, the JC virus is believed to require interaction with the 5HT2A receptor and the Merkel cell virus with heparan sulfate.[15][17] However, in general virus-cell interactions are mediated by commonly occurring molecules on the cell surface, and therefore are likely not a major contributor to individual viruses' observed cell-type tropism.[15] After binding to molecules on the cell surface, the virion is endocytosed and enters the endoplasmic reticulum - a behavior unique among known non-enveloped viruses[18] - where the viral capsid structure is likely to be disrupted by action of host cell disulfide isomerase enzymes.[2][12][19]

The details of transit to the nucleus are not clear and may vary among individual polyomaviruses. It has been frequently reported that an intact, albeit distorted, virion particle is released from the endoplasmic reticulum into the cell cytoplasm, where the genome is released from the capsid, possibly due to the low calcium concentration in the cytoplasm.[18] Both expression of viral genes and replication of the viral genome occur in the nucleus using host cell machinery. The early genes - comprising at minimum the small tumor antigen (ST) and large tumor antigen (LT) - are expressed first, from a single alternatively spliced messenger RNA strand. These proteins serve to manipulate the host's cell cycle - dysregulating the transition from G1 phase to S phase, when the host cell's genome is replicated - because host cell DNA replication machinery is needed for viral genome replication.[2][12][15] The precise mechanism of this dysregulation depends on the virus; for example, SV40 LT can directly bind host cell p53, but murine polyomavirus LT does not.[20] LT induces DNA replication from the viral genome's non-coding control region (NCCR), after which expression of the early mRNA is reduced and expression of the late mRNA, which encodes the viral capsid proteins, begins.[19] As these interactions begin, the LTs belonging to several polyomaviruses, including Merkel cell polyomavirus, present oncogenic potential.[21] Several mechanisms have been described for regulating the transition from early to late gene expression, including the involvement of the LT protein in repressing the early promoter,[19] the expression of un-terminated late mRNAs with extensions complementary to early mRNA,[15] and the expression of regulatory microRNA.[15] Expression of the late genes results in accumulation of the viral capsid proteins in the host cell cytoplasm. Capsid components enter the nucleus in order to encapsidate new viral genomic DNA. New virions may be assembled in viral factories.[2][12] The mechanism of viral release from the host cell varies among polyomaviruses; some express proteins that facilitate cell exit, such as the agnoprotein or VP4.[19] In some cases high levels of encapsidated virus result in cell lysis, releasing the virions.[15]

Viral proteins

Tumor antigens

The large tumor antigen plays a key role in regulating the viral life cycle by binding to the viral origin of DNA replication where it promotes DNA synthesis. Also as the polyomavirus relies on the host cell machinery to replicate the host cell needs to be in s-phase for this to begin. Due to this, large T-antigen also modulates cellular signaling pathways to stimulate progression of the cell cycle by binding to a number of cellular control proteins.[22] This is achieved by a two prong attack of inhibiting tumor suppressing genes p53 and members of the retinoblastoma (pRB) family,[23] and stimulating cell growth pathways by binding cellular DNA, ATPase-helicase, DNA polymerase α association, and binding of transcription preinitiation complex factors.[24] This abnormal stimulation of the cell cycle is a powerful force for oncogenic transformation.

The small tumor antigen protein is also able to activate several cellular pathways that stimulate cell proliferation. Polyomavirus small T antigens commonly target protein phosphatase 2A (PP2A),[25] a key multisubunit regulator of multiple pathways including Akt, the mitogen-activated protein kinase (MAPK) pathway, and the stress-activated protein kinase (SAPK) pathway.[26][27] Merkel cell polyomavirus small T antigen encodes a unique domain, called the LT-stabilization domain (LSD), that binds to and inhibits the FBXW7 E3 ligase regulating both cellular and viral oncoproteins.[28] Unlike for SV40, the MCV small T antigen directly transforms rodent cells in vitro.[29]

The middle tumor antigen is used in model organisms developed to study cancer, such as the MMTV-PyMT system where middle T is coupled to the MMTV promoter. There it functions as an oncogene, while the tissue where the tumor develops is determined by the MMTV promoter.

Capsid proteins

The polyomavirus capsid consists of one major component, major capsid protein VP1, and one or two minor components, minor capsid proteins VP2 and VP3. VP1 pentamers form the closed icosahedral viral capsid, and in the interior of the capsid each pentamer is associated with one molecule of either VP2 or VP3.[5][30] Some polyomaviruses, such as Merkel cell polyomavirus, do not encode or express VP3.[31] The capsid proteins are expressed from the late region of the genome.[5]

Agnoprotein

The agnoprotein is a small multifunctional phospho-protein found in the late coding part of the genome of some polyomaviruses, most notably BK virus, JC virus, and SV40. It is essential for proliferation in the viruses that express it and is thought to be involved in regulating the viral life cycle, particularly replication and viral exit from the host cell, but the exact mechanisms are unclear.[32][33]

Taxonomy

The polyomaviruses are members of group I (dsDNA viruses). The classification of polyomaviruses has been the subject of several proposed revisions as new members of the group are discovered. Formerly, polyomaviruses and papillomaviruses, which share many structural features but have very different genomic organizations, were classified together in the now-obsolete family Papovaviridae.[34] (The name Papovaviridae derived from three abbreviations: Pa for Papillomavirus, Po for Polyomavirus, and Va for "vacuolating.")[35] The polyomaviruses were divided into three major clades (that is, genetically-related groups): the SV40 clade, the avian clade, and the murine polyomavirus clade.[36] A subsequent proposed reclassification by the International Committee on Taxonomy of Viruses (ICTV) recommended dividing the family of Polyomaviridae into three genera:[37]

  • Genus Orthopolyomavirus (type species SV40)
  • Genus Wukipolyomavirus (type species KI polyomavirus)
  • Genus Avipolyomavirus (type species Avian polyomavirus)

The current ICTV classification system recognises six genera and 117 species, of which five could not be assigned a genus. This system retains the distinction between avian and mammalian viruses, grouping the avian subset into the genus Gammapolyomavirus. The six genera are:[3]

  • Alphapolyomavirus
  • Betapolyomavirus
  • Deltapolyomavirus
  • Epsilonpolyomavirus
  • Gammapolyomavirus
  • Zetapolyomavirus

The following species are unassigned to a genus:[3]

  • Centropristis striata polyomavirus 1
  • Rhynchobatus djiddensis polyomavirus 1
  • Sparus aurata polyomavirus 1
  • Trematomus bernacchii polyomavirus 1
  • Trematomus pennellii polyomavirus 1

Description of additional viruses is ongoing. These include the sea otter polyomavirus 1[38] and Alpaca polyomavirus[39] Another virus is the giant panda polyomavirus 1.[40] Another virus has been described from sigmodontine rodents.[41] Another - tree shrew polyomavirus 1 - has been described in the tree shrew.[42]

Human polyomaviruses

Most polyomaviruses do not infect humans. Of the polyomaviruses cataloged as of 2017, a total of 14 were known with human hosts.[4] However, some polyomaviruses are associated with human disease, particularly in immunocompromised individuals. MCV is highly divergent from the other human polyomaviruses and is most closely related to murine polyomavirus. Trichodysplasia spinulosa-associated polyomavirus (TSV) is distantly related to MCV. Two viruses—HPyV6 and HPyV7—are most closely related to KI and WU viruses, while HPyV9 is most closely related to the African green monkey-derived lymphotropic polyomavirus (LPV).

A fourteenth virus has been described.[43] Lyon IARC polyomavirus is related to raccoon polyomavirus.

List of human polyomaviruses

The following 14 polyomaviruses with human hosts had been identified and had their genomes sequenced as of 2017:[4]

SpeciesProposed genusVirus nameAbbreviationNCBI RefSeqYear of discoveryClinical correlate (if any)References
Human polyomavirus 5AlphaMerkel cell polyomavirusMCPyVNC_0102772008Merkel cell cancer[5][44][11][45]
Human polyomavirus 8AlphaTrichodysplasia spinulosa polyomavirusTSPyVNC_0143612010Trichodysplasia spinulosa[5][46][47]
Human polyomavirus 9AlphaHuman polyomavirus 9HPyV9NC_0151502011None known[48]
Human polyomavirus 12AlphaHuman polyomavirus 12HPyV12NC_0208902013None known[49]
Human polyomavirus 13AlphaNew Jersey polyomavirusNJPyVNC_0241182014None known[50]
Human polyomavirus 1BetaBK polyomavirusBKPyVNC_0015381971Polyomavirus-associated nephropathy; haemorrhagic cystitis[5][51]
Human polyomavirus 2BetaJC polyomavirusJCPyVNC_0016991971Progressive multifocal leukoencephalopathy[5][52]
Human polyomavirus 3BetaKI polyomavirusKIPyVNC_0092382007None known[53]
Human polyomavirus 4BetaWU polyomavirusWUPyVNC_0095392007None known[14]
Human polyomavirus 6DeltaHuman polyomavirus 6HPyV6NC_0144062010HPyV6 associated pruritic and dyskeratotic dermatosis (H6PD)[54][31]
Human polyomavirus 7DeltaHuman polyomavirus 7HPyV7NC_0144072010HPyV7-related epithelial hyperplasia[54][55][56][31]
Human polyomavirus 10DeltaMW polyomavirusMWPyVNC_0181022012None known[57][58][59]
Human polyomavirus 11DeltaSTL polyomavirusSTLPyVNC_0201062013None known[60]
Human polyomavirus 14 Alpha Lyon IARC polyomavirus LIPyV NC_034253.1 2017 None known [61][62]

Deltapolyomavirus contains only the four human viruses shown in the above table. The Alpha and Beta groups contain viruses that infect a variety of mammals. The Gamma group contains the avian viruses.[4] Clinically significant disease associations are shown only where causality is expected.[5][63]

Antibodies to the monkey lymphotropic polyomavirus have been detected in humans suggesting that this virus - or a closely related virus - can infect humans.[64]

Clinical relevance

All the polyomaviruses are highly common childhood and young adult infections.[65] Most of these infections appear to cause little or no symptoms. These viruses are probably lifelong persistent among almost all adults. Diseases caused by human polyomavirus infections are most common among immunocompromised people; disease associations include BK virus with nephropathy in renal transplant and non-renal solid organ transplant patients,[8][9] JC virus with progressive multifocal leukoencephalopathy,[10] and Merkel cell virus (MCV) with Merkel cell cancer.[11]

SV40
Main article: SV40

SV40 replicates in the kidneys of monkeys without causing disease, but can cause cancer in rodents under laboratory conditions. In the 1950s and early 1960s, well over 100 million people may have been exposed to SV40 due to previously undetected SV40 contamination of polio vaccine, prompting concern about the possibility that the virus might cause disease in humans.[66][67] Although it has been reported as present in some human cancers, including brain tumors, bone tumors, mesotheliomas, and non-Hodgkin's lymphomas,[68] accurate detection is often confounded by high levels of cross-reactivity for SV40 with widespread human polyomaviruses.[67] Most virologists dismiss SV40 as a cause for human cancers.[66][69][70]

Diagnosis

The diagnosis of polyomavirus almost always occurs after the primary infection as it is either asymptomatic or sub-clinical. Antibody assays are commonly used to detect presence of antibodies against individual viruses.[71] Competition assays are frequently needed to distinguish among highly similar polyomaviruses.[72]

In cases of progressive multifocal leucoencephalopathy (PML), a cross-reactive antibody to SV40 T antigen (commonly Pab419) is used to stain tissues directly for the presence of JC virus T antigen. PCR can be used on a biopsy of the tissue or cerebrospinal fluid to amplify the polyomavirus DNA. This allows not only the detection of polyomavirus but also which sub type it is.[73]

There are three main diagnostic techniques used for the diagnosis of the reactivation of polyomavirus in polyomavirus nephropathy (PVN): urine cytology, quantification of the viral load in both urine and blood, and a renal biopsy.[71] The reactivation of polyomavirus in the kidneys and urinary tract causes the shedding of infected cells, virions, and/or viral proteins in the urine. This allows urine cytology to examine these cells, which if there is polyomavirus inclusion of the nucleus, is diagnostic of infection.[74] Also as the urine of an infected individual will contain virions and/or viral DNA, quantitation of the viral load can be done through PCR.[75] This is also true for the blood.

Renal biopsy can also be used if the two methods just described are inconclusive or if the specific viral load for the renal tissue is desired. Similarly to the urine cytology, the renal cells are examined under light microscopy for polyomavirus inclusion of the nucleus, as well as cell lysis and viral partials in the extra cellular fluid. The viral load as before is also measure by PCR.

Tissue staining using a monoclonal antibody against MCV T antigen shows utility in differentiating Merkel cell carcinoma from other small, round cell tumors.[76] Blood tests to detect MCV antibodies have been developed and show that infection with the virus is widespread although Merkel cell carcinoma patients have exceptionally higher antibody responses than asymptomatically infected persons.[7][77][78][79]

Use in tracing human migration

The JC virus offers a promising genetic marker for human evolution and migration.[80] It is carried by 70–90 percent of humans and is usually transmitted from parents to offspring. This method does not appear to be reliable for tracing the recent African origin of modern humans.

History

Murine polyomavirus was the first polyomavirus discovered, having been reported by Ludwik Gross in 1953 as an extract of mouse leukemias capable of inducing parotid gland tumors.[81] The causative agent was identified as a virus by Sarah Stewart and Bernice Eddy, after whom it was once called "SE polyoma".[82][83][84] The term "polyoma" refers to the viruses' ability to produce multiple (poly-) tumors (-oma) under certain conditions. The name has been criticized as a "meatless linguistic sandwich" ("meatless" because both morphemes in "polyoma" are affixes) giving little insight into the viruses' biology; in fact, subsequent research has found that most polyomaviruses rarely cause clinically significant disease in their host organisms under natural conditions.[85]

Dozens of polyomaviruses have been identified and sequenced as of 2017, infecting mainly birds and mammals. Two polyomaviruses are known to infect fish, the black sea bass[86] and gilthead seabream.[87] A total of fourteen polyomaviruses are known to infect humans.[4]

References
  1. Moens U, Calvignac-Spencer S, Lauber C, Ramqvist T, Feltkamp MC, Daugherty MD, Verschoor EJ, Ehlers B (June 2017). "ICTV Virus Taxonomy Profile: Polyomaviridae". The Journal of General Virology. 98 (6): 1159–1160. doi:10.1099/jgv.0.000839. PMC 5656788. PMID 28640744.
  2. "ICTV Report Polyomaviridae".
  3. "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 10 May 2021.
  4. Calvignac-Spencer S, Feltkamp MC, Daugherty MD, Moens U, Ramqvist T, Johne R, Ehlers B (June 2016). "A taxonomy update for the family Polyomaviridae". Archives of Virology. 161 (6): 1739–50. doi:10.1007/s00705-016-2794-y. PMID 26923930.
  5. DeCaprio JA, Garcea RL (April 2013). "A cornucopia of human polyomaviruses". Nature Reviews. Microbiology. 11 (4): 264–76. doi:10.1038/nrmicro2992. PMC 3928796. PMID 23474680.
  6. Gossai A, Waterboer T, Nelson HH, Michel A, Willhauck-Fleckenstein M, Farzan SF, Hoen AG, Christensen BC, Kelsey KT, Marsit CJ, Pawlita M, Karagas MR (January 2016). "Seroepidemiology of Human Polyomaviruses in a US Population". American Journal of Epidemiology. 183 (1): 61–9. doi:10.1093/aje/kwv155. PMC 5006224. PMID 26667254.
  7. Kean JM, Rao S, Wang M, Garcea RL (March 2009). "Seroepidemiology of human polyomaviruses". PLOS Pathogens. 5 (3): e1000363. doi:10.1371/journal.ppat.1000363. PMC 2655709. PMID 19325891.
  8. Jamboti JS (August 2016). "BK virus nephropathy in renal transplant recipients". Nephrology. 21 (8): 647–54. doi:10.1111/nep.12728. PMID 26780694.
  9. Kuppachi S, Kaur D, Holanda DG, Thomas CP (April 2016). "BK polyoma virus infection and renal disease in non-renal solid organ transplantation". Clinical Kidney Journal. 9 (2): 310–8. doi:10.1093/ckj/sfv143. PMC 4792618. PMID 26985385.
  10. Adang L, Berger J (2015). "Progressive Multifocal Leukoencephalopathy". F1000Research. 4: 1424. doi:10.12688/f1000research.7071.1. PMC 4754031. PMID 26918152.
  11. Feng H, Shuda M, Chang Y, Moore PS (February 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". Science. 319 (5866): 1096–100. Bibcode:2008Sci...319.1096F. doi:10.1126/science.1152586. PMC 2740911. PMID 18202256.
  12. "Viral Zone". ExPASy. Retrieved 15 June 2015.
  13. Salunke DM, Caspar DL, Garcea RL (September 1986). "Self-assembly of purified polyomavirus capsid protein VP1". Cell. 46 (6): 895–904. doi:10.1016/0092-8674(86)90071-1. PMID 3019556. S2CID 25800023.
  14. Gaynor AM, Nissen MD, Whiley DM, Mackay IM, Lambert SB, Wu G, Brennan DC, Storch GA, Sloots TP, Wang D (May 2007). "Identification of a novel polyomavirus from patients with acute respiratory tract infections". PLOS Pathogens. 3 (5): e64. doi:10.1371/journal.ppat.0030064. PMC 1864993. PMID 17480120.
  15. International Agency for Research on Cancer (2013). "Introduction to Polyomaviruses" (PDF). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. 104: 121–131.
  16. Buch MH, Liaci AM, O'Hara SD, Garcea RL, Neu U, Stehle T (October 2015). "Structural and Functional Analysis of Murine Polyomavirus Capsid Proteins Establish the Determinants of Ligand Recognition and Pathogenicity". PLOS Pathogens. 11 (10): e1005104. doi:10.1371/journal.ppat.1005104. PMC 4608799. PMID 26474293.
  17. Schowalter RM, Pastrana DV, Buck CB (July 2011). "Glycosaminoglycans and sialylated glycans sequentially facilitate Merkel cell polyomavirus infectious entry". PLOS Pathogens. 7 (7): e1002161. doi:10.1371/journal.ppat.1002161. PMC 3145800. PMID 21829355.
  18. Inoue T, Tsai B (January 2013). "How viruses use the endoplasmic reticulum for entry, replication, and assembly". Cold Spring Harbor Perspectives in Biology. 5 (1): a013250. doi:10.1101/cshperspect.a013250. PMC 3579393. PMID 23284050.
  19. Gjoerup O, Chang Y (2010). "Update on human polyomaviruses and cancer". Advances in Cancer Research. 106: 1–51. doi:10.1016/S0065-230X(10)06001-X. ISBN 9780123747716. PMID 20399955.
  20. Andrabi S, Hwang JH, Choe JK, Roberts TM, Schaffhausen BS (2011). "Comparisons between Murine Polyomavirus and Simian Virus 40 Show Significant Differences in Small T Antigen Function". Journal of Virology. 85 (20): 10649–10658. doi:10.1128/JVI.05034-11. PMC 3187521. PMID 21835797.
  21. Rotondo JC, Bononi I, Puozzo A, Govoni M, Foschi V, Lanza G, Gafà R, Gaboriaud P, Touzé FA, Selvatici R, Martini F, Tognon M (July 2017). "Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF". Clinical Cancer Research. 23 (14): 3929–3934. doi:10.1158/1078-0432.CCR-16-2899. PMID 28174236.
  22. White MK, Gordon J, Reiss K, Del Valle L, Croul S, Giordano A, Darbinyan A, Khalili K (December 2005). "Human polyomaviruses and brain tumors". Brain Research. Brain Research Reviews. 50 (1): 69–85. doi:10.1016/j.brainresrev.2005.04.007. PMID 15982744. S2CID 20990837.
  23. Kazem S, van der Meijden E, Wang RC, Rosenberg AS, Pope E, Benoit T, Fleckman P, Feltkamp MC (2014). "Polyomavirus-associated Trichodysplasia spinulosa involves hyperproliferation, pRB phosphorylation and upregulation of p16 and p21". PLOS ONE. 9 (10): e108947. Bibcode:2014PLoSO...9j8947K. doi:10.1371/journal.pone.0108947. PMC 4188587. PMID 25291363.
  24. Kelley WL, Georgopoulos C (April 1997). "The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone". Proceedings of the National Academy of Sciences of the United States of America. 94 (8): 3679–84. Bibcode:1997PNAS...94.3679K. doi:10.1073/pnas.94.8.3679. PMC 20500. PMID 9108037.
  25. Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM (January 1990). "Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A". Cell. 60 (1): 167–76. doi:10.1016/0092-8674(90)90726-u. PMID 2153055. S2CID 2007706.
  26. Sontag E, Fedorov S, Kamibayashi C, Robbins D, Cobb M, Mumby M (December 1993). "The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation". Cell. 75 (5): 887–97. doi:10.1016/0092-8674(93)90533-V. PMID 8252625.
  27. Watanabe G, Howe A, Lee RJ, Albanese C, Shu IW, Karnezis AN, Zon L, Kyriakis J, Rundell K, Pestell RG (November 1996). "Induction of cyclin D1 by simian virus 40 small tumor antigen". Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12861–6. Bibcode:1996PNAS...9312861W. doi:10.1073/pnas.93.23.12861. PMC 24011. PMID 8917510.
  28. Kwun HJ, Shuda M, Feng H, Camacho CJ, Moore PS, Chang Y (August 2013). "Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7". Cell Host & Microbe. 14 (2): 125–35. doi:10.1016/j.chom.2013.06.008. PMC 3764649. PMID 23954152.
  29. Shuda M, Kwun HJ, Feng H, Chang Y, Moore PS (September 2011). "Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator". The Journal of Clinical Investigation. 121 (9): 3623–34. doi:10.1172/JCI46323. PMC 3163959. PMID 21841310.
  30. Chen XS, Stehle T, Harrison SC (June 1998). "Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry". The EMBO Journal. 17 (12): 3233–40. doi:10.1093/emboj/17.12.3233. PMC 1170661. PMID 9628860.
  31. Schowalter RM, Pastrana DV, Pumphrey KA, Moyer AL, Buck CB (June 2010). "Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin". Cell Host & Microbe. 7 (6): 509–15. doi:10.1016/j.chom.2010.05.006. PMC 2919322. PMID 20542254.
  32. Sariyer IK, Saribas AS, White MK, Safak M (May 2011). "Infection by agnoprotein-negative mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in DNA content". Virology Journal. 8: 255. doi:10.1186/1743-422X-8-255. PMC 3127838. PMID 21609431.
  33. Saribas AS, Coric P, Hamazaspyan A, Davis W, Axman R, White MK, Abou-Gharbia M, Childers W, Condra JH, Bouaziz S, Safak M (October 2016). "Emerging From the Unknown: Structural and Functional Features of Agnoprotein of Polyomaviruses". Journal of Cellular Physiology. 231 (10): 2115–27. doi:10.1002/jcp.25329. PMC 5217748. PMID 26831433.
  34. "ICTV Taxonomy Website".
  35. International Agency for Research on Cancer (2013). "IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. Malaria and Some Polyomaviruses (SV40, BK, JC, and Merkel Cell Viruses)". IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. 104.
  36. Pérez-Losada M, Christensen RG, McClellan DA, Adams BJ, Viscidi RP, Demma JC, Crandall KA (June 2006). "Comparing phylogenetic codivergence between polyomaviruses and their hosts". Journal of Virology. 80 (12): 5663–9. doi:10.1128/JVI.00056-06. PMC 1472594. PMID 16731904.
  37. Johne R, Buck CB, Allander T, Atwood WJ, Garcea RL, Imperiale MJ, Major EO, Ramqvist T, Norkin LC (September 2011). "Taxonomical developments in the family Polyomaviridae". Archives of Virology. 156 (9): 1627–34. doi:10.1007/s00705-011-1008-x. PMC 3815707. PMID 21562881.
  38. Siqueira JD, Ng TF, Miller M, Li L, Deng X, Dodd E, Batac F, Delwart E (July 2017). "Endemic infection of stranded southern sea otters (Enhydra lutris nereis) with novel parvovirus, polyomavirus, and adenovirus". Journal of Wildlife Diseases. 53 (3): 532–542. doi:10.7589/2016-04-082. PMID 28192039. S2CID 46740584.
  39. Dela Cruz FN, Li L, Delwart E, Pesavento PA (2017). "A novel pulmonary polyomavirus in alpacas (Vicugna pacos)". Veterinary Microbiology. 201: 49–55. doi:10.1016/j.vetmic.2017.01.005. PMID 28284622.
  40. Qi D, Shan T, Liu Z, Deng X, Zhang Z, Bi W, Owens JR, Feng F, Zheng L, Huang F, Delwart E, Hou R, Zhang W (2017). "A novel polyomavirus from the nasal cavity of a giant panda (Ailuropoda melanoleuca)". Virology Journal. 14 (1): 207. doi:10.1186/s12985-017-0867-5. PMC 5658932. PMID 29078783.
  41. Gonçalves Motta Maia F, Marciel de Souza W, Sabino-Santos G, Jorge Fumagalli M, Modha S, Ramiro Murcia P, Tadeu Moraes Figueiredo L (2018). "A novel polyomavirus in sigmodontine rodents from São Paulo State, Brazil". Archives of Virology. 163 (10): 2913–2915. doi:10.1007/s00705-018-3913-8. PMID 29931397. S2CID 49351836.
  42. Liu P, Qiu Y, Xing C, Zhou JH, Yang WH, Wang Q, Li JY, Han X, Zhang YZ, Ge XY (2019). "Detection and genome characterization of two novel papillomaviruses and a novel polyomavirus in tree shrew (Tupaia belangeri chinensis) in China". Virol J. 16 (1): 35. doi:10.1186/s12985-019-1141-9. PMC 6423848. PMID 30885224.
  43. Gheit T, Dutta S, Oliver J, Robitaille A, Hampras S, Combes JD, McKay-Chopin S, Le Calvez-Kelm F, Fenske N, Cherpelis B, Giuliano AR, Franceschi S, McKay J, Rollison DE, Tommasino M (2017). "Isolation and characterization of a novel putative human polyomavirus". Virology. 506: 45–54. doi:10.1016/j.virol.2017.03.007. PMC 9265179. PMID 28342387.
  44. Altman LK (18 January 2008). "Virus Is Linked to a Powerful Skin Cancer". The New York Times. Retrieved 18 January 2008.
  45. Shuda M, Arora R, Kwun HJ, Feng H, Sarid R, Fernández-Figueras MT, Tolstov Y, Gjoerup O, Mansukhani MM, Swerdlow SH, Chaudhary PM, Kirkwood JM, Nalesnik MA, Kant JA, Weiss LM, Moore PS, Chang Y (September 2009). "Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors". International Journal of Cancer. 125 (6): 1243–9. doi:10.1002/ijc.24510. PMC 6388400. PMID 19499546.
  46. van der Meijden E, Janssens RW, Lauber C, Bouwes Bavinck JN, Gorbalenya AE, Feltkamp MC (July 2010). "Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient". PLOS Pathogens. 6 (7): e1001024. doi:10.1371/journal.ppat.1001024. PMC 2912394. PMID 20686659.
  47. Kazem S, van der Meijden E, Feltkamp MC (August 2013). "The trichodysplasia spinulosa-associated polyomavirus: virological background and clinical implications". APMIS. 121 (8): 770–82. doi:10.1111/apm.12092. PMID 23593936. S2CID 13734654.
  48. Scuda N, Hofmann J, Calvignac-Spencer S, Ruprecht K, Liman P, Kühn J, Hengel H, Ehlers B (May 2011). "A novel human polyomavirus closely related to the african green monkey-derived lymphotropic polyomavirus". Journal of Virology. 85 (9): 4586–90. doi:10.1128/jvi.02602-10. PMC 3126223. PMID 21307194.
  49. Korup S, Rietscher J, Calvignac-Spencer S, Trusch F, Hofmann J, Moens U, Sauer I, Voigt S, Schmuck R, Ehlers B (2013). "Identification of a novel human polyomavirus in organs of the gastrointestinal tract". PLOS ONE. 8 (3): e58021. Bibcode:2013PLoSO...858021K. doi:10.1371/journal.pone.0058021. PMC 3596337. PMID 23516426.
  50. Mishra N, Pereira M, Rhodes RH, An P, Pipas JM, Jain K, Kapoor A, Briese T, Faust PL, Lipkin WI (November 2014). "Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy". The Journal of Infectious Diseases. 210 (10): 1595–9. doi:10.1093/infdis/jiu250. PMC 4334791. PMID 24795478.
  51. Gardner SD, Field AM, Coleman DV, Hulme B (June 1971). "New human papovavirus (B.K.) isolated from urine after renal transplantation". Lancet. 1 (7712): 1253–7. doi:10.1016/s0140-6736(71)91776-4. PMID 4104714.
  52. Padgett BL, Walker DL, ZuRhein GM, Eckroade RJ, Dessel BH (June 1971). "Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy". Lancet. 1 (7712): 1257–60. doi:10.1016/S0140-6736(71)91777-6. PMID 4104715.
  53. Allander T, Andreasson K, Gupta S, Bjerkner A, Bogdanovic G, Persson MA, Dalianis T, Ramqvist T, Andersson B (April 2007). "Identification of a third human polyomavirus". Journal of Virology. 81 (8): 4130–6. doi:10.1128/JVI.00028-07. PMC 1866148. PMID 17287263.
  54. Nguyen KD, Lee EE, Yue Y, Stork J, Pock L, North JP, Vandergriff T, Cockerell C, Hosler GA, Pastrana DV, Buck CB, Wang RC (May 2017). "Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses". Journal of the American Academy of Dermatology. 76 (5): 932–940.e3. doi:10.1016/j.jaad.2016.11.035. PMC 5392424. PMID 28040372.
  55. Ho J, Jedrych JJ, Feng H, Natalie AA, Grandinetti L, Mirvish E, Crespo MM, Yadav D, Fasanella KE, Proksell S, Kuan SF, Pastrana DV, Buck CB, Shuda Y, Moore PS, Chang Y (May 2015). "Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients". The Journal of Infectious Diseases. 211 (10): 1560–5. doi:10.1093/infdis/jiu524. PMC 4425822. PMID 25231015.
  56. Toptan T, Yousem SA, Ho J, Matsushima Y, Stabile LP, Fernández-Figueras MT, Bhargava R, Ryo A, Moore PS, Chang Y (February 2016). "Survey for human polyomaviruses in cancer". JCI Insight. 1 (2). doi:10.1172/jci.insight.85562. PMC 4811373. PMID 27034991.
  57. Siebrasse EA, Reyes A, Lim ES, Zhao G, Mkakosya RS, Manary MJ, Gordon JI, Wang D (October 2012). "Identification of MW polyomavirus, a novel polyomavirus in human stool". Journal of Virology. 86 (19): 10321–6. doi:10.1128/JVI.01210-12. PMC 3457274. PMID 22740408.
  58. Buck CB, Phan GQ, Raiji MT, Murphy PM, McDermott DH, McBride AA (October 2012). "Complete genome sequence of a tenth human polyomavirus". Journal of Virology. 86 (19): 10887. doi:10.1128/JVI.01690-12. PMC 3457262. PMID 22966183.
  59. Yu G, Greninger AL, Isa P, Phan TG, Martínez MA, de la Luz Sanchez M, Contreras JF, Santos-Preciado JI, Parsonnet J, Miller S, DeRisi JL, Delwart E, Arias CF, Chiu CY (2012). "Discovery of a novel polyomavirus in acute diarrheal samples from children". PLOS ONE. 7 (11): e49449. Bibcode:2012PLoSO...749449Y. doi:10.1371/journal.pone.0049449. PMC 3498111. PMID 23166671.
  60. Lim ES, Reyes A, Antonio M, Saha D, Ikumapayi UN, Adeyemi M, Stine OC, Skelton R, Brennan DC, Mkakosya RS, Manary MJ, Gordon JI, Wang D (February 2013). "Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing". Virology. 436 (2): 295–303. doi:10.1016/j.virol.2012.12.005. PMC 3693558. PMID 23276405.
  61. Gheit, Tarik; Dutta, Sankhadeep; Oliver, Javier; Robitaille, Alexis; Hampras, Shalaka; Combes, Jean-Damien; McKay-Chopin, Sandrine; Calvez-Kelm, Florence Le; Fenske, Neil (2017). "Isolation and characterization of a novel putative human polyomavirus". Virology. 506: 45–54. doi:10.1016/j.virol.2017.03.007. PMC 9265179. PMID 28342387.
  62. Prado JC, Monezi TA, Amorim AT, Lino V, Paladino A, Boccardo E (2018). "Human polyomaviruses and cancer: an overview". Clinics (Sao Paulo). 73 (suppl 1): e558s. doi:10.6061/clinics/2018/e558s. PMC 6157077. PMID 30328951.
  63. Dalianis T, Hirsch HH (March 2013). "Human polyomaviruses in disease and cancer". Virology. 437 (2): 63–72. doi:10.1016/j.virol.2012.12.015. PMID 23357733.
  64. Van Ghelue M, Khan MT, Ehlers B, Moens U (November 2012). "Genome analysis of the new human polyomaviruses". Reviews in Medical Virology. 22 (6): 354–77. doi:10.1002/rmv.1711. PMID 22461085.
  65. Egli A, Infanti L, Dumoulin A, Buser A, Samaridis J, Stebler C, Gosert R, Hirsch HH (March 2009). "Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors". The Journal of Infectious Diseases. 199 (6): 837–46. doi:10.1086/597126. PMID 19434930.
  66. Poulin DL, DeCaprio JA (September 2006). "Is there a role for SV40 in human cancer?". Journal of Clinical Oncology. 24 (26): 4356–65. doi:10.1200/JCO.2005.03.7101. PMID 16963733.
  67. zur Hausen H (December 2003). "SV40 in human cancers--an endless tale?". International Journal of Cancer. 107 (5): 687. doi:10.1002/ijc.11517. PMID 14566815.
  68. Gazdar AF, Butel JS, Carbone M (December 2002). "SV40 and human tumours: myth, association or causality?". Nature Reviews. Cancer. 2 (12): 957–64. doi:10.1038/nrc947. PMID 12459734. S2CID 8878662.
  69. Carroll-Pankhurst C, Engels EA, Strickler HD, Goedert JJ, Wagner J, Mortimer EA (November 2001). "Thirty-five year mortality following receipt of SV40- contaminated polio vaccine during the neonatal period". British Journal of Cancer. 85 (9): 1295–7. doi:10.1054/bjoc.2001.2065. PMC 2375249. PMID 11720463.
  70. Shah KV (January 2007). "SV40 and human cancer: a review of recent data". International Journal of Cancer. 120 (2): 215–23. doi:10.1002/ijc.22425. PMID 17131333. S2CID 20679358.
  71. Drachenberg CB, Hirsch HH, Ramos E, Papadimitriou JC (December 2005). "Polyomavirus disease in renal transplantation: review of pathological findings and diagnostic methods". Human Pathology. 36 (12): 1245–55. doi:10.1016/j.humpath.2005.08.009. PMID 16311117.
  72. Viscidi RP, Clayman B (2006). "Serological Cross Reactivity between Polyomavirus Capsids". In Ahsan N (ed.). Polyomaviruses and Human Diseases. Advances in Experimental Medicine and Biology. Vol. 577. pp. 73–84. doi:10.1007/0-387-32957-9_5. ISBN 978-0-387-29233-5. PMID 16626028.
  73. Drews K, Bashir T, Dörries K (January 2000). "Quantification of human polyomavirus JC in brain tissue and cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy by competitive PCR". Journal of Virological Methods. 84 (1): 23–36. doi:10.1016/S0166-0934(99)00128-7. PMID 10644084.
  74. Nickeleit V, Hirsch HH, Binet IF, Gudat F, Prince O, Dalquen P, Thiel G, Mihatsch MJ (May 1999). "Polyomavirus infection of renal allograft recipients: from latent infection to manifest disease". Journal of the American Society of Nephrology. 10 (5): 1080–9. doi:10.1681/ASN.V1051080. PMID 10232695.
  75. Randhawa PS, Vats A, Zygmunt D, Swalsky P, Scantlebury V, Shapiro R, Finkelstein S (August 2002). "Quantitation of viral DNA in renal allograft tissue from patients with BK virus nephropathy". Transplantation. 74 (4): 485–8. doi:10.1097/00007890-200208270-00009. PMID 12352906. S2CID 30574884.
  76. Busam KJ, Jungbluth AA, Rekthman N, Coit D, Pulitzer M, Bini J, Arora R, Hanson NC, Tassello JA, Frosina D, Moore P, Chang Y (September 2009). "Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas". The American Journal of Surgical Pathology. 33 (9): 1378–85. doi:10.1097/PAS.0b013e3181aa30a5. PMC 2932664. PMID 19609205.
  77. Tolstov YL, Pastrana DV, Feng H, Becker JC, Jenkins FJ, Moschos S, Chang Y, Buck CB, Moore PS (September 2009). "Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays". International Journal of Cancer. 125 (6): 1250–6. doi:10.1002/ijc.24509. PMC 2747737. PMID 19499548.
  78. Pastrana DV, Tolstov YL, Becker JC, Moore PS, Chang Y, Buck CB (September 2009). "Quantitation of human seroresponsiveness to Merkel cell polyomavirus". PLOS Pathogens. 5 (9): e1000578. doi:10.1371/journal.ppat.1000578. PMC 2734180. PMID 19750217.
  79. Carter JJ, Paulson KG, Wipf GC, Miranda D, Madeleine MM, Johnson LG, Lemos BD, Lee S, Warcola AH, Iyer JG, Nghiem P, Galloway DA (November 2009). "Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma". Journal of the National Cancer Institute. 101 (21): 1510–22. doi:10.1093/jnci/djp332. PMC 2773184. PMID 19776382.
  80. Elizabeth Matisoo-Smith; K. Ann Horsburgh (2012). DNA for Archaeologists. Routledge. ISBN 978-1598746815.
  81. Gross L (June 1953). "A filterable agent, recovered from Ak leukemic extracts, causing salivary gland carcinomas in C3H mice". Proceedings of the Society for Experimental Biology and Medicine. 83 (2): 414–21. doi:10.3181/00379727-83-20376. PMID 13064287. S2CID 34223353.
  82. Stewart SE, Eddy BE, Borgese N (June 1958). "Neoplasms in mice inoculated with a tumor agent carried in tissue culture". Journal of the National Cancer Institute. 20 (6): 1223–43. doi:10.1093/jnci/20.6.1223. PMID 13549981.
  83. Eddy BE, Stewart SE (November 1959). "Characteristics of the SE polyoma virus". American Journal of Public Health and the Nation's Health. 49 (11): 1486–92. doi:10.2105/AJPH.49.11.1486. PMC 1373056. PMID 13819251.
  84. Schowalter RM, Pastrana DV, Buck CB (July 2011). "Glycosaminoglycans and sialylated glycans sequentially facilitate Merkel cell polyomavirus infectious entry". PLOS Pathogens. 7 (7): e1002161. doi:10.1371/journal.ppat.1002161. PMC 3145800. PMID 21829355.
  85. Gottlieb KA, Villarreal LP (June 2001). "Natural biology of polyomavirus middle T antigen". Microbiology and Molecular Biology Reviews. 65 (2): 288–318, second and third pages, table of contents. doi:10.1128/mmbr.65.2.288-318.2001. PMC 99028. PMID 11381103.
  86. Peretti A, FitzGerald PC, Bliskovsky V, Pastrana DV, Buck CB (January 2015). "Genome Sequence of a Fish-Associated Polyomavirus, Black Sea Bass (Centropristis striata) Polyomavirus 1". Genome Announcements. 3 (1): e01476-14. doi:10.1128/genomeA.01476-14. PMC 4319505. PMID 25635011.
  87. López-Bueno A, Mavian C, Labella AM, Castro D, Borrego JJ, Alcami A, Alejo A (October 2016). "Concurrence of Iridovirus, Polyomavirus, and a Unique Member of a New Group of Fish Papillomaviruses in Lymphocystis Disease-Affected Gilthead Sea Bream". Journal of Virology. 90 (19): 8768–79. doi:10.1128/JVI.01369-16. PMC 5021401. PMID 27440877.
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