SB-200646

SB-200646 is a 5-HT2 receptor antagonist with anxiolytic properties in rats. It was the first 5-HT2 antagonist discovered to have selectivity of 5-HT2C/2B over 5-HT2A.[1]

SB-200646
Clinical data
ATC code
  • none
Legal status
Legal status
  • UN: Unscheduled
Identifiers
  • 1-(1-Methyl-1H-indol-5-yl)-3-pyridin-3-ylurea
CAS Number
PubChem CID
ChemSpider
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H14N4O
Molar mass266.304 g·mol−1
3D model (JSmol)
  • Cn1ccc2c1ccc(c2)NC(=O)Nc3cccnc3
  • InChI=1S/C15H14N4O/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13/h2-10H,1H3,(H2,17,18,20)
  • Key:OJZZJTLBYXHUSJ-UHFFFAOYSA-N

References

  1. Kennett GA, Wood MD, Glen A, Grewal S, Forbes I, Gadre A, Blackburn TP (March 1994). "In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist". British Journal of Pharmacology. 111 (3): 797–802. doi:10.1111/j.1476-5381.1994.tb14808.x. PMC 1910094. PMID 7912626.
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