Sercloremine

Sercloremine (CGP-4718A), usually as the hydrochloride salt, is a drug which was developed in the 1980s and was formerly under investigation as an antidepressant, but was never marketed.[1][2] It acts as a selective, reversible inhibitor of monoamine oxidase A (RIMA) and serotonin reuptake inhibitor.[1][3]

Sercloremine
Names
Preferred IUPAC name
4-(5-Chloro-1-benzofuran-2-yl)-1-methylpiperidine
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C14H16ClNO/c1-16-6-4-10(5-7-16)14-9-11-8-12(15)2-3-13(11)17-14/h2-3,8-10H,4-7H2,1H3
    Key: FTKTZRKAVSDSRA-UHFFFAOYSA-N
  • CN1CCC(CC1)C2=CC3=C(O2)C=CC(=C3)Cl
Properties
C14H16ClNO
Molar mass 249.74 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. Luttinger D, Hlasta DJ (January 1987). "Antidepressant agents". In Hesp B, Bailey DM (eds.). Annual Reports in Medicinal Chemistry. Vol. 22. Academic Press. pp. 21–30 (25). ISBN 978-0-08-058366-2.
  2. Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1801–. ISBN 978-0-412-46630-4.
  3. Delini-Stula A, Fischbach R, Gnirss F, Bures E, Pöldinger W (1985). "Early experience with CGP 4718 A (Sercloremine), a new selective and reversible MAO-A and 5-HT-uptake inhibitor, in the treatment of depressive patients". Drug Development Research. 6 (4): 371–384. doi:10.1002/ddr.430060409. ISSN 0272-4391. S2CID 85113482.


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