WAY-208466

WAY-208466 is a potent and highly selective full agonist of the 5-HT6 receptor.[1] It increases GABA levels in the cerebral cortex and tolerance does not appear to occur to this action upon chronic administration.[1] Animal studies have shown that WAY-208466 produces antidepressant and anxiolytic effects in rodents and it may also be useful in the treatment of obsessive-compulsive disorder.[1][2]

WAY-208466
Skeletal formula of WAY-208,466
Clinical data
ATC code
  • none
Identifiers
  • 2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-1-yl}-N,N-dimethylethanamine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC17H18FN3O2S
Molar mass347.41 g·mol−1
3D model (JSmol)
  • CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC=CC(=C3)F

See also

References
  1. Schechter LE, Lin Q, Smith DL, et al. (May 2008). "Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466". Neuropsychopharmacology. 33 (6): 1323–35. doi:10.1038/sj.npp.1301503. PMID 17625499.
  2. Carr GV, Schechter LE, Lucki I (March 2010). "Antidepressant and anxiolytic effects of selective 5-HT(6) receptor agonists in rats". Psychopharmacology. 213 (2–3): 499–507. doi:10.1007/s00213-010-1798-7. PMC 2910165. PMID 20217056.
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