Activated protein C–protein C inhibitor

Activated protein C–protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI).[1][2][3] It has been measured in coagulation testing to evaluate coagulation, thrombosis, and other cardiovascular complications.[2][3][4] It is a marker of thrombin generation and indicates hypercoagulability.[1][5] The half-life of APC-PCI is either 40 minutes or 140 minutes.[1]

Ethinylestradiol-containing birth control pills have been found to increase levels of APC-PCI to a similar degree as thrombin–antithrombin complex (TAT) and to a greater extent than D-dimer.[5] However, only APC-PCI was able to differentiate between a second- and third-generation birth control pill.[5]

Another complex related to APC-PCI is the activated protein C–α1-antitrypsin (APCAT) complex.[1]

References
  1. Merlini PA, Ardissino D (1995). "Laboratory Measurement of Thrombin Activity--What Every Clinician Scientist Needs to Know". J Thromb Thrombolysis. 2 (2): 85–92. doi:10.1007/BF01064374. PMID 10608009. S2CID 28203940.
  2. Lippi G, Cervellin G, Franchini M, Favaloro EJ (November 2010). "Biochemical markers for the diagnosis of venous thromboembolism: the past, present and future". J Thromb Thrombolysis. 30 (4): 459–71. doi:10.1007/s11239-010-0460-x. PMID 20213258. S2CID 23806848.
  3. Davies RS, Abdelhamid M, Wall ML, Vohra RK, Bradbury AW, Adam DJ (September 2011). "Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm". J Vasc Surg. 54 (3): 865–78. doi:10.1016/j.jvs.2011.04.010. PMID 21684711.
  4. Misra S, Kumar A, Kumar P, Yadav AK, Mohania D, Pandit AK, Prasad K, Vibha D (September 2017). "Blood-based protein biomarkers for stroke differentiation: A systematic review". Proteomics Clin Appl. 11 (9–10). doi:10.1002/prca.201700007. PMID 28452132. S2CID 13676815.
  5. Bremme K, Hamad RR, Berg E, Strandberg K, Stenflo J (October 2012). "The APC-PCI concentration as an early marker of activation of blood coagulation: a study of women on combined oral contraceptives". Thromb Res. 130 (4): 636–9. doi:10.1016/j.thromres.2011.11.006. PMID 22154243.



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