Tissue factor pathway inhibitor

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.

TFPI
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
External IDsOMIM: 152310 MGI: 1095418 HomoloGene: 4579 GeneCards: TFPI
Orthologs
SpeciesHumanMouse
Entrez

7035

21788

Ensembl

ENSG00000003436

ENSMUSG00000027082

UniProt

P10646

O54819

RefSeq (mRNA)

NM_001177319
NM_001177320
NM_011576
NM_001355271
NM_001355273

RefSeq (protein)

NP_001170790
NP_001170791
NP_035706
NP_001342200
NP_001342202

Location (UCSC)Chr 2: 187.46 – 187.57 MbChr 2: 84.26 – 84.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Genetics

The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. A similar gene, termed TFPI2, has been identified on chromosome 7, at locus 7q21.3; in addition to TFPI activity, its product also has retinal pigment epithelial cell growth-promoting properties.

Protein structure

TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region.

TFPI consists of a highly negatively charged amino-terminus, three tandemly linked Kunitz domains, and a highly positively charged carboxy-terminus. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypsin inhibitor and bovine basic pancreatic trypsin inhibitor.

Interactions

Tissue factor pathway inhibitor has been shown to interact with Factor X.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000003436 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027082 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Broze, G J; Warren L A; Novotny W F; Higuchi D A; Girard J J; Miletich J P (Feb 1988). "The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action". Blood. UNITED STATES. 71 (2): 335–43. doi:10.1182/blood.V71.2.335.335. ISSN 0006-4971. PMID 3422166.

Further reading

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