Angiopoietin receptor

The angiopoietin receptors are receptors that bind angiopoietin.

Angiopoietin receptor
Identifiers
SymbolTIE
PfamPF10430
InterProIPR018941
Membranome1214
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
SymbolTIE1
Alt. symbolsTIE, JTK14
NCBI gene7075
HGNC11809
OMIM600222
RefSeqNM_005424
UniProtP35590
Other data
EC number2.7.1.112
LocusChr. 1 p34-p33
Search for
StructuresSwiss-model
DomainsInterPro
TEK tyrosine kinase, endothelial
Identifiers
SymbolTEK
Alt. symbolsTIE2, TIE-2, VMCM1, CD202b
NCBI gene7010
HGNC11724
OMIM600221
RefSeqNM_000459
UniProtQ02763
Other data
LocusChr. 9 p21
Search for
StructuresSwiss-model
DomainsInterPro

TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).

Angiopoietins

The angiopoietins are protein growth factors that regulate angiogenesis, the formation of blood vessels. In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4).[1] Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by binding their physiologic receptors, Tie-1 and Tie-2. These are receptor tyrosine kinases, so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating cell signalling.

It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation. But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.

See also
  • Angiopoietin#Tie pathway

References
  1. Jeltsch M, Leppanen VM, Saharinen P, Alitalo K (2013). "Receptor Tyrosine Kinase-Mediated Angiogenesis". Cold Spring Harbor Perspectives in Biology. 5 (9): a009183. doi:10.1101/cshperspect.a009183. PMC 3753715. PMID 24003209.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.