GNF6702

GNF6702 is the name for a broad-spectrum antiprotozoal drug invented by researchers working at the Genomics Institute of the Novartis Research Foundation in 2013,[1] with activity against leishmaniasis, Chagas disease and sleeping sickness. These three diseases are caused by related kinetoplastid parasites, which share similar biology. GNF6702 acts as allosteric proteasome inhibitor which was effective against infection with any of the three protozoal diseases in mice, while having little evident toxicity to mammalian cells.[2]

GNF6702
Identifiers
IUPAC name
  • N-[4-fluoro-3-(6-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
Chemical and physical data
FormulaC22H16FN7O3
Molar mass429.406 g·mol−1
3D model (JSmol)
SMILES
  • n5ccccc5-c(cn1n4)cnc1nc4-c3cc(ccc3F)NC(=O)c2oc(C)nc2C
InChI
  • InChI=1S/C22H16FN7O2/c1-12-19(32-13(2)26-12)21(31)27-15-6-7-17(23)16(9-15)20-28-22-25-10-14(11-30(22)29-20)18-5-3-4-8-24-18/h3-11H,1-2H3,(H,27,31)
  • Key:WXZFCGRYVWYYTG-UHFFFAOYSA-N

See also

References
  1. US 2015175613, Biggart A, et al., "Compounds and compositions for the treatment of parasitic diseases", published 25 June 2015, assigned to Novartis AG
  2. Khare S, Nagle AS, Biggart A, Lai YH, Liang F, Davis LC, et al. (September 2016). "Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness". Nature. 537 (7619): 229–233. doi:10.1038/nature19339. PMC 5161665. PMID 27501246.


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