Itramin tosilate

Itramin tosilate (INN), or itramin tosylate (more commonly), is a vasodilator.[1][2][3][4][5][6]

Itramin tosilate
Clinical data
Trade namesNilatil
Other namesItramin tosylate
ATC code
Identifiers
IUPAC name
  • 2-aminoethyl nitrate; 4-methylbenzenesulfonic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC9H14N2O6S
Molar mass278.28 g·mol−1
3D model (JSmol)
SMILES
  • CC1=CC=C(C=C1)S(=O)(=O)O.C(CO[N+](=O)[O-])N
InChI
  • InChI=1S/C7H8O3S.C2H6N2O3/c1-6-2-4-7(5-3-6)11(8,9)10;3-1-2-7-4(5)6/h2-5H,1H3,(H,8,9,10);1-3H2
  • Key:HPPBBWMYZVALRK-UHFFFAOYSA-N

References
  1. Batterman RC, Mouratoff GJ (June 1963). "Anginal syndrome. Treatment with a long-acting nitrate (itramin tosylate)". California Medicine. 98: 318–9. PMC 1575756. PMID 13966844.
  2. McGrath JC (June 2013). "2-Aminoethylnitrate: Earlier investigation as a drug was missed by recent authors due to changes in nomenclature". British Journal of Pharmacology. 169 (4): 949–50. doi:10.1111/bph.12148. PMC 3687673. PMID 23711023.
  3. Ehrenberger W (August 1960). "[On the effects of 2-aminoethylnitrate p-toluenesulfonate (Nilatil) on coronary circulation disorders]". Wiener Zeitschrift für Innere Medizin und Ihre Grenzgebiete. 41: 323–4. PMID 13725976.
  4. Fremont RE (May 1967). "Clinical and cardiographic evaluation of a new nitrate, itramin tosylate". Current Therapeutic Research, Clinical and Experimental. 9 (5): 235–46. PMID 4963057.
  5. Kinnard WJ, Vogin EE, Aceto MD, Buckley JP (July 1964). "The Coronary Vasodilatory Effects of 2-Aminoethlynitrate p-Toluenesulfonate". Angiology. 15 (7): 312–5. doi:10.1177/000331976401500703. PMID 14177999. S2CID 29870356.
  6. Takenaka F, Umeda T (July 1976). "Effects of propranolo, itramin tosylate and dipyridamole on myocardial phosphate metabolism in anoxic perfused rat hearts". Archives Internationales de Pharmacodynamie et de Therapie. 222 (1): 45–54. PMID 10860.


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