Glycogen storage disease type V

[1]Glycogen storage disease type V (GSD5, GSD-V), also known as McArdle's disease,[2] is a metabolic disorder, more specifically a muscle glycogen storage disease, caused by a deficiency of myophosphorylase.[3][4] Its incidence is reported as one in 100,000,[5] roughly the same as glycogen storage disease type I.[2]

Glycogen storage disease type V
Other namesMcArdle disease, muscle phosphorylase (myophosphorylase) deficiency
Muscle biopsy specimen showing vacuolar myopathy: The patient had a type V glycogenosis (McArdle disease)
SpecialtyEndocrinology 

The disease was first reported in 1951 by Dr. Brian McArdle of Guy's Hospital, London.[6]

Signs and symptoms

The onset of this disease is usually noticed in childhood,[7] but often not diagnosed until the third or fourth decade of life. Symptoms include exercise intolerance with muscle pain, early fatigue, painful cramps, and myoglobin in the urine (often provoked by a bout of exercise).[2] Myoglobinuria may result from the breakdown of skeletal muscle known as rhabdomyolysis, a condition in which muscle cells breakdown, sending their contents into the bloodstream.

Patients may exhibit a “second wind” phenomenon. This is characterized by the patient's better tolerance for aerobic exercise such as walking and cycling after approximately 10 minutes.[8] This is attributed to the combination of increased blood flow and the ability of the body to find alternative sources of energy, like fatty acids and proteins. In the long term, patients may exhibit kidney failure due to the myoglobinuria, and with age, patients may exhibit progressively increasing weakness and substantial muscle loss.

Younger people may display unusual symptoms, such as difficulty in chewing, swallowing or utilizing normal oral motor functions.[9]

Patients may present at emergency rooms with severe fixed contractures of the muscles and often severe pain. These require urgent assessment for rhabdomyolysis as in about 30% of cases this leads to acute kidney injury. Left untreated, this can be life-threatening. In a small number of cases compartment syndrome has developed, requiring prompt surgical referral.

Genetics

"GSDV is inherited in an autosomal recessive manner. At conception, each sibling of an affected individual has a 25% chance of being affected, a 50% chance of being a carrier, and a 25% chance of being unaffected and not a carrier."[9]

Two autosomal recessive forms of this disease occur, childhood-onset and adult-onset. The gene for myophosphorylase, PYGM (the muscle-type of the glycogen phosphorylase gene), is located on chromosome 11q13. According to the most recent publications, 95 different mutations have been reported. The forms of the mutations may vary between ethnic groups. For example, the R50X (Arg50Stop) mutation (previously referred to as R49X) is most common in North America and western Europe, and the Y84X mutation is most common among central Europeans.

The exact method of protein disruption has been elucidated in certain mutations. For example, R138W is known to disrupt to pyridoxal phosphate binding site.[10] In 2006, another mutation (c.13_14delCT) was discovered which may contribute to increased symptoms in addition to the common Arg50Stop mutation.[11]

Structure

The myophosphorylase structure consists of 842 amino acids. Its molecular weight of the unprocessed precursor is 97 kDa. The three-dimensional structure has been determined for this protein. The interactions of several amino acids in myophosphorylase's structure are known. Ser-14 is modified by phosphorylase kinase during activation of the enzyme. Lys-680 is involved in binding the pyridoxal phosphate, which is the active form of vitamin B6, a cofactor required by myophosphorylase. By similarity, other sites have been estimated: Tyr-76 binds AMP, Cys-109 and Cys-143 are involved in subunit association, and Tyr-156 may be involved in allosteric control.

Function

Myophosphorylase is the form of the glycogen phosphorylase found in muscle that catalyses the following reaction:[12][13][14]

((1→4)-alpha-D-glucosyl) (n) + phosphate = ((1→4)-alpha-D-glucosyl) (n-1) + alpha-D-glucose 1-phosphate

Failure of this enzyme ultimately impairs the operation of ATPases. This is due to the lack of normal pH fall during exercise, which impairs the creatine kinase equilibrium and exaggerates the rise of ADP.

Pathophysiology

Myophosphorylase is involved in the breakdown of glycogen to glucose for use in muscle. The enzyme removes 1,4 glycosyl residues from outer branches of glycogen and adds inorganic phosphate to form glucose-1-phosphate. Ordinarily, the removal of 1,4 glycosyl residues by myophosphorylase leads to the formation of glucose-1-phosphate during glycogen breakdown and the polar, phosphorylated glucose cannot leave the cell membrane and so is marked for intracellular catabolism. In McArdle's Disease, deficiency of myophosphorylase leads to accumulation of intramuscular glycogen and a lack of glucose-1-phosphate for cellular fuel.

Myophosphorylase exists in the active form when phosphorylated. The enzyme phosphorylase kinase plays a role in phosphorylating glycogen phosphorylase to activate it and another enzyme, protein phosphatase-1, inactivates glycogen phosphorylase through dephosphorylation.

Diagnosis

There are some laboratory tests that may aid in diagnosis of GSD-V. A muscle biopsy will note the absence of myophosphorylase in muscle fibers. In some cases, acid-Schiff stained glycogen can be seen with microscopy.

Genetic sequencing of the PYGM gene (which codes for the muscle isoform of glycogen phosphorylase[15][16]) may be done to determine the presence of gene mutations, determining if McArdle's is present. This type of testing is considerably less invasive than a muscle biopsy.[9]

The physician can also perform an ischemic forearm exercise test as described above. Some findings suggest a nonischemic test could be performed with similar results.[17] The nonischemic version of this test would involve not cutting off the blood flow to the exercising arm. Findings consistent with McArdle's disease would include a failure of lactate in venous blood and exaggerated ammonia levels. These findings would indicate a severe muscle glycolytic block.

Serum lactate may fail to rise in part because of increased uptake via the monocarboxylate transporter (MCT1), which is upregulated in skeletal muscle in McArdle disease. Lactate may be used as a fuel source once converted to pyruvate. Ammonia levels may rise given ammonia is a by-product of the adenylate kinase pathway, an alternative pathway for ATP production. In this pathway, two ADP molecules combine to make ATP; AMP is deaminated in this process, producing inosine monophosphate (IMP) and ammonia (NH3).[18]

Physicians may also check resting levels of creatine kinase, which are moderately increased in 90% of patients. In some, the level is increased by multitudes - a person without GSD-V will have a CK between 60 and 400IU/L, while a person with the syndrome may have a level of 5,000 IU/L at rest, and may increase to 35,000 IU/L or more with muscle exertion. This can help distinguish McArdle's syndrome from carnitine palmitoyltransferase II deficiency (CPT-II), a lipid-based metabolic disorder which prevents fatty acids from being transported into mitochondria for use as an energy source. Also, serum electrolytes and endocrine studies (such as thyroid function, parathyroid function and growth hormone levels) will also be completed. Urine studies are required only if rhabdomyolysis is suspected. Urine volume, urine sediment and myoglobin levels would be ascertained. If rhabdomyolysis is suspected, serum myoglobin, creatine kinase, lactate dehydrogenase, electrolytes and renal function will be checked.

Treatment

Supervised exercise programs have been shown in small studies to improve exercise capacity by several measures.[19][20]

Oral sucrose treatment (for example a sports drink with 75 grams of sucrose in 660 ml.) taken 30 minutes prior to exercise has been shown to help improve exercise tolerance including a lower heart rate and lower perceived level of exertion compared with placebo.[21]

A low dosage treatment with creatine showed a significant improvement of muscle problems compared to placebo in a small clinical study.[22]

History

The deficiency was the first metabolic myopathy to be recognized, when Dr. McArdle described the first case in a 30-year-old man who always experienced pain and weakness after exercise. Dr. McArdle noticed this patient's cramps were electrically silent and his venous lactate levels failed to increase upon ischemic exercise. (The ischemic exercise consists of the patient squeezing a hand dynamometer at maximal strength for a specific period of time, usually a minute, with a blood pressure cuff, which is placed on the upper arm and set at 250 mmHg, blocking blood flow to the exercising arm.) Notably, this is the same phenomenon that occurs when muscle is poisoned by iodoacetate, a substance that blocks breakdown of glycogen into glucose and prevents the formation of lactate. Dr. McArdle accurately concluded that the patient had a disorder of glycogen breakdown that specifically affected skeletal muscle. The associated enzyme deficiency was discovered in 1959 by W. F. H. M. Mommaerts et al.[23]

References
  1. Bissonnette, Bruno; Luginbuehl, Igor; Engelhardt, Thomas (2019), "Glycogen Storage Disease Type V (GSD V)", Syndromes: Rapid Recognition and Perioperative Implications (2 ed.), New York, NY: McGraw-Hill Education, retrieved 2021-12-12
  2. Nagaraju, Kanneboyina; Lundberg, Ingrid E. (2013). "Inflammatory Diseases of Muscle and Other Myopathies". Kelley's Textbook of Rheumatology. pp. 1404–1430.e5. doi:10.1016/b978-1-4377-1738-9.00085-2. ISBN 978-1-4377-1738-9.
  3. Rubio JC, Garcia-Consuegra I, Nogales-Gadea G, et al. (2007). "A proposed molecular diagnostic flowchart for myophosphorylase deficiency (McArdle disease) in blood samples from Spanish patients". Hum. Mutat. 28 (2): 203–4. doi:10.1002/humu.9474. PMID 17221871.
  4. Valberg, Stephanie J. (2008). "Skeletal Muscle Function". Clinical Biochemistry of Domestic Animals. pp. 459–484. doi:10.1016/b978-0-12-370491-7.00015-5. ISBN 978-0-12-370491-7.
  5. http://mcardlesdisease.org/
  6. Brian McArdle at Who Named It?
  7. Wolfe GI, Baker NS, Haller RG, Burns DK, Barohn RJ (2000). "McArdle's disease presenting with asymmetric, late-onset arm weakness". Muscle Nerve. 23 (4): 641–5. doi:10.1002/(SICI)1097-4598(200004)23:4<641::AID-MUS25>3.0.CO;2-M. PMID 10716777. S2CID 22423841.
  8. Pearson CM, Rimer DG, Mommaerts WF (April 1961). "A metabolic myopathy due to absence of muscle phosphorylase". Am. J. Med. 30 (4): 502–17. doi:10.1016/0002-9343(61)90075-4. PMID 13733779.
  9. Martín, Miguel A.; Lucia, Alejandro; Arenas, Joaquin; Andreu, Antonio L. (1993). "Glycogen Storage Disease Type V". GeneReviews®. University of Washington, Seattle. PMID 20301518.
  10. Martin, M. A.; Rubio, J. C.; Wevers, R. A.; Van Engelen, B. G. M.; Steenbergen, G. C. H.; Van Diggelen, O. P.; Visser, M. De; Die-Smulders, C. De; Blazquez, A.; Andreu, A. L.; Arenas, J. (January 2004). "Molecular Analysis of Myophosphorylase Deficiency in Dutch Patients with McArdle's Disease". Annals of Human Genetics. 68 (1): 17–22. doi:10.1046/j.1529-8817.2003.00067.x. PMID 14748827. S2CID 41149417.
  11. Rubio, Juan C.; Lucia, Alejandro; Fernández-Cadenas, Israel; Cabello, Ana; Blázquez, Alberto; Gámez, Josep; Andreu, Antoni L.; Martín, Miguel A.; Arenas, Joaquin (1 December 2006). "Novel Mutation in the PYGM Gene Resulting in McArdle Disease". Archives of Neurology. 63 (12): 1782. doi:10.1001/archneur.63.12.1782. PMID 17172620.
  12. "PYGM - Glycogen phosphorylase, muscle form - Homo sapiens (Human) - PYGM gene & protein". www.uniprot.org. Retrieved 2018-08-31. This article incorporates text available under the CC BY 4.0 license.
  13. "UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.
  14. "Reaction participants of glycogen phosphorylase". www.rhea-db.org. Retrieved 2020-12-26.
  15. NCBI Gene ID 5837: PYGM phosphorylase, glycogen, muscle, retrieved 22 May 2013
  16. "PYGM", NLM Genetics Home Reference, retrieved 22 May 2013
  17. Kazemi-Esfarjani P, Skomorowska E, Jensen TD, Haller RG, Vissing J (2002). "A nonischemic forearm exercise test for McArdle disease". Ann. Neurol. 52 (2): 153–9. doi:10.1002/ana.10263. PMID 12210784. S2CID 43237025.
  18. Kitaoka, Y. (2014). "McArdle Disease and Exercise Physiology". Biology. 3 (1): 157–66. doi:10.3390/biology3010157. PMC 4009758. PMID 24833339.
  19. Perez, M; Moran, M; Cardona, C; Mate-Munoz, J L; Rubio, J C; Andreu, A L; Martin, M A; Arenas, J; Lucia, A; St C Gibson, A (4 October 2006). "Can patients with McArdle's disease run?". British Journal of Sports Medicine. 41 (1): 53–54. doi:10.1136/bjsm.2006.030791. PMC 2465149. PMID 17000713.
  20. Haller, Ronald G.; Wyrick, Phil; Taivassalo, Tanja; Vissing, John (June 2006). "Aerobic conditioning: An effective therapy in McArdle's disease". Annals of Neurology. 59 (6): 922–928. doi:10.1002/ana.20881. PMID 16718692. S2CID 31921729.
  21. Vissing, John; Haller, Ronald G. (25 December 2003). "The Effect of Oral Sucrose on Exercise Tolerance in Patients with McArdle's Disease". New England Journal of Medicine. 349 (26): 2503–2509. doi:10.1056/NEJMoa031836. PMID 14695410.
  22. Vorgerd, M.; Grehl, T.; Jäger, M; Müller, K; Freitag, G; Patzold, T; Bruns, N; Fabian, K; Tegenthoff, M; Mortier, W; Luttmann, A; Zange, J; Malin, J. P (1 July 2000). "Creatine Therapy in Myophosphorylase Deficiency (McArdle Disease): A Placebo-Controlled Crossover Trial". Archives of Neurology. 57 (7): 956–963. doi:10.1001/archneur.57.7.956. PMID 10891977.
  23. Mommaerts, W. F. H. M; Illingworth, Barbara; Pearson, Carl M.; Guillory, R. J.; Seraydarian, K. (22 April 1959). "A Functional Disorder of Muscle Associated with the Absence of Phosphorylase". Proceedings of the National Academy of Sciences. 45 (6): 791–797. Bibcode:1959PNAS...45..791M. doi:10.1073/pnas.45.6.791. PMC 222638. PMID 16590445.
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