Oxolamine

Oxolamine is a cough suppressant[1] that is available as a generic drug in many jurisdictions.[2]

Oxolamine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.012.267
Chemical and physical data
FormulaC14H19N3O
Molar mass245.326 g·mol−1
3D model (JSmol)
SMILES
  • n1c(onc1c2ccccc2)CCN(CC)CC
InChI
  • InChI=1S/C14H19N3O/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12/h5-9H,3-4,10-11H2,1-2H3 Y
  • Key:IDCHQQSVJAAUQQ-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

Oxolamine also has anti-inflammatory activity, which causes a reduction in irritation of the nerve receptors of the respiratory tract.[3]

It is mainly used for the treatment of pharyngitis, tracheitis, bronchitis, bronchiectasis and pertussis.[3]

Oxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant. It is listed as a prescription drug in New Zealand legislation. Oxolamine is also approved in Taiwan for the treatment of respiratory tract inflammation.[4]

References
  1. de Groot AC (2022). "3.357 Oxolamine". Systemic Drugs. Monographs in Contact Allergy. Vol. 4 (First ed.). CRC Press. p. 712. ISBN 978-1-00-054991-1.
  2. "Oxolamine". drugs.com. 19 April 2015.
  3. "NCATS Inxight Drugs — OXOLAMINE CITRATE". drugs.ncats.io. Retrieved 2022-09-26.
  4. "Oxolamine". go.drugbank.com. Retrieved 2022-09-26.


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