Pentamycin

Pentamycin, also called fungichromin, is a macrolide antimicrobial. Pentamycin is a polyene antifungal antibiotic obtained from Streptomyces pentaticus. It is used in the treatment of vaginal candidiasis, for the protozoal infection trichomoniasis, and mixed infections. A 3 mg vaginal pessary is inserted once or twice daily for 5-10 days. It is also used to treat pulmonary aspergillosis as a dry powder inhalation system.[1]

Pentamycin
Clinical data
Routes of
administration		Vaginal pessary
ATC code
Identifiers
IUPAC name
  • (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.027.194
Chemical and physical data
FormulaC35H58O12
Molar mass670.837 g·mol−1
InChI
  • InChI=1S/C35H58O12/c1-4-5-11-16-29(41)32-30(42)20-26(38)18-24(36)17-25(37)19-27(39)21-31(43)34(45)33(44)22(2)14-12-9-7-6-8-10-13-15-28(40)23(3)47-35(32)46/h6-10,12-15,23-34,36-45H,4-5,11,16-21H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,22-14+/t23-,24+,25-,26+,27-,28+,29-,30+,31-,32-,33-,34-/m1/s1 Y
  • Key:AGJUUQSLGVCRQA-SWOUQTJZSA-N Y
  (verify)

References
  1. Kranzler M (2012). Pentamycin - a new option for the treatment of infections with Trichomonas vaginalis? (Ph.D. thesis) (1. Auflage, digitale Originalausgabe ed.). München: Universität Wien. ISBN 978-3-656-14565-3.
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