Sodium aurothiosulfate

Sodium aurothiosulfate, or sanocrysin, is the inorganic compound with the formula Na3Au(S2O3)2·2H2O. This salt contains an anionic coordination complex of gold(I) bound to two thiosulfate ligands. It is colorless.[1][2]

Sodium aurothiosulfate
Clinical data
Routes of
administration		Intramuscular injection
ATC code
Identifiers
IUPAC name
  • Sodium bis(thiosulphate) aurate(I), dihydrate
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaAuNa3O6S4
Molar mass490.17 g·mol−1
  (verify)

History

The compound was first synthesized in 1845 by Mathurin-Joseph Fordos and A. Gélis who were researching chemicals used in the Daguerrotype photographic process. It then came to be called Fordos and Gélis salt.[3][4] It went out of interest until 1924 when it was noted as a chemotherapeutic agent for tuberculosis by Holger Møllgaard in Copenhagen.[5] Other methods of synthesis were then identified.[6]

Potential applications

Like several other gold compounds, this species is used as an antirheumatic.[7] The first placebo-controlled trial was probably conducted in 1931, when sanocrysin was compared with distilled water for the treatment of tuberculosis.[8]

Aurothiosulfate complexes have been discussed in the context of the extraction of gold from its ores. The general approach would employ sodium or ammonium thiosulfate in place of cyanide salts as lixiviants.[9][10]

References
  1. Baggio RF, Baggio S (1973). "Crystal and molecular structure of trisodium dithiosulphate aurate(I), dihydrate, Na3[Au(S2O3)2],2H2O". Journal of Inorganic and Nuclear Chemistry. 35 (9): 3191–3200. doi:10.1016/0022-1902(73)80019-3.
  2. Tobön-Zapata G, Etcheverry SB, Baran EJ (1997). "Vibrational spectrum of Sanocrysin". Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 53 (2): 183–188. Bibcode:1997AcSpA..53..183T. doi:10.1016/S1386-1425(97)83024-7.
  3. Fordos, M.-J.; Gélis, A. (1843). "Recherches sur la liqueur d'or employée en photographie". C.-R. Acad. Sc. (Paris). 17: 629–630.
  4. Fordos, M.-J.; Gélis, A. (1845). "Action du perchlorure d'or sur l'hyposulfite de soude". Ann. Chim. Phys. 3. 13: 394–404.
  5. "Current Topics and Events". Nature. 115 (2886): 272–277. 1925. doi:10.1038/115272c0. ISSN 0028-0836.
  6. McCluskey, K. Lucille; Eichelberger, Lillian (1926). "New methods for the preparation of sodium aurothiosulfate". Journal of the American Chemical Society. 48 (1): 136–139. doi:10.1021/ja01412a018. ISSN 0002-7863.
  7. Shaw III CF (September 1999). "Gold-based therapeutic agents". Chemical Reviews. 99 (9): 2589–600. doi:10.1021/cr980431o. PMID 11749494.
  8. Emanuel EJ, Crouch RA, Arras JD, Moreno JD, Grady C, eds. (2003). Ethical and regulatory aspects of clinical research: readings and commentary. Johns Hopkins University Press. p. 140. ISBN 978-0801878138.
  9. Aylmore MG, Muir DM (2001). "Thiosulfate Leaching of Gold - a Review". Minerals Engineering. 14 (2): 135–174. doi:10.1016/s0892-6875(00)00172-2.
  10. Barbera, J. J.; Metzger, A.; Wolf, M. "Sulfites, Thiosulfates, and Dithionites". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a25_477.

Source of Chemical Formula: http://medical.merriam-webster.com/medical/gold%20sodium%20thiomalate

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