Synthetic vaccine

A synthetic vaccine is a vaccine consisting mainly of synthetic peptides, carbohydrates, or antigens. They are usually considered to be safer than vaccines from bacterial cultures. Creating vaccines synthetically has the ability to increase the speed of production. This is especially important in the event of a pandemic.

History

The world's first synthetic vaccine was created in 1796 from diphtheria toxin by Louis Chedid (scientist) from the Pasteur Institute and Michael Sela from the Weizmann Institute.

In 1986, Manuel Elkin Patarroyo created the SPf66, the first version of a synthetic vaccine for Malaria.[1]

During the H1N1 outbreak in 2009, vaccines only became available in large quantities after the peak of human infections. This was a learning experience for vaccination companies. Novartis Vaccine and Diagnostics, among other companies, developed a synthetic approach that very rapidly generates vaccine viruses from sequence data in order to be able to administer vaccinations early in the pandemic outbreak. Philip Dormatizer, the leader of viral vaccine research at Novartis, says they have "developed a way of chemically synthesizing virus genomes and growing them in tissue culture cells".[2]

Phase I data of UB-311, a synthetic peptide vaccine targeting amyloid beta, showed that the drug was able to generate antibodies to specific amyloid beta oligomers and fibrils with no decrease in antibody levels in patients of advanced age. Results from the Phase II trial are expected in the second half of 2018.[3][4]

References
  1. Patarroyo, Manuel E. (May 30, 2007). "Synthetic vaccine update: Applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization". Vaccine. 25, 22 (22): 4487–4501. doi:10.1016/j.vaccine.2007.03.016. PMID 17403557.
  2. Young Rojahn, Susan (May 14, 2013). "Synthetic Biology Could Speed Flu Vaccine Production". MIT Technology Review.
  3. http://www.bioworld.com/content/alz-players-stand-united-new-beta-bids-also-fall%5B%5D
  4. Wang, Chang Yi; Wang, Pei-Ning; Chiu, Ming-Jang; Finstad, Connie L; Lin, Feng; Lynn, Shugene; Tai, Yuan-Hung; De Fang, Xin; Zhao, Kesheng; Hung, Chung-Ho; Tseng, Yiting; Peng, Wen-Jiun; Wang, Jason; Yu, Chih-Chieh; Kuo, Be-Sheng; Frohna, Paul A (2017). "UB-311, a novel UBITh ® amyloid β peptide vaccine for mild Alzheimer's disease". Alzheimer's & Dementia: Translational Research & Clinical Interventions. 3 (2): 262–272. doi:10.1016/j.trci.2017.03.005. PMC 5651432. PMID 29067332.
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