TachoSil

TachoSil is a collagen sponge coated with the human coagulation factors fibrinogen and thrombin.[3] It is used during surgery to stop local bleeding on internal organs (hemostasis). The sponge is manufactured from horse tendons. TachoSil reacts upon contact with blood, other body fluids or saline to form a clot that glues it to the tissue surface. Hemostasis is reached in a few minutes, and the sponge is absorbed by the body within several weeks.

TachoSil
Combination of
FibrinogenGlycoprotein
ThrombinCoagulation factor
Clinical data
Trade namesTachoSil
AHFS/Drugs.comProfessional Drug Facts
Routes of
administration		Epilesional
ATC code
Legal status
Legal status
  • UK: POM (Prescription only) [1]
  • EU: Rx-only [2]
Identifiers
CAS Number
DrugBank
UNII

Some patients experience hypersensitivity or allergic reactions. In rare cases, it could turn into severe hypersensitive reaction. Those who are prone to having a systemic reaction to horse proteins or human blood products are not good candidates for use of TachoSil.

See also

References
  1. "TachoSil sealant matrix - Summary of Product Characteristics (SmPC)". (emc). 31 January 2020. Retrieved 9 July 2020.
  2. "TachoSil EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 9 July 2020.
  3. Colombo GL, Bettoni D, Di Matteo S, Grumi C, Molon C, Spinelli D, Mauro G, Tarozzo A, Bruno GM (2014). "Economic and outcomes consequences of TachoSil®: a systematic review". Vascular Health and Risk Management. 10: 569–75. doi:10.2147/VHRM.S63199. PMC 4166367. PMID 25246797.
  • "TachoSil". Drug Information Portal. U.S. National Library of Medicine.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.