Talnetant

Talnetant (SB-223,412) is a neurokinin 3 receptor antagonist developed by GlaxoSmithKline, which is being researched for several functions (primarily treatment of irritable bowel syndrome, despite a 2007 study finding no statistically significant improvement in rectal hypersensitivity over placebo). Its use as a potential antipsychotic drug for the treatment of schizophrenia has also been discontinued.[1][2][3][4]

Talnetant
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ECHA InfoCard100.236.526
Chemical and physical data
FormulaC25H22N2O2
Molar mass382.463 g·mol−1
3D model (JSmol)
SMILES
  • CCC(C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)O
InChI
  • InChI=1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29) N
  • Key:BIAVGWDGIJKWRM-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

See also
  • Tachykinin receptor 3 § Agonists

References
  1. "UPDATE 1-GlaxoSmithKline prunes new drug pipeline". Reuters. Oct 15, 2007.
  2. Evangelista S (July 2005). "Talnetant GlaxoSmithKline". Current Opinion in Investigational Drugs. 6 (7): 717–21. PMID 16044668.
  3. Houghton LA, Cremonini F, Camilleri M, Busciglio I, Fell C, Cox V, et al. (September 2007). "Effect of the NK(3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans". Neurogastroenterology and Motility. 19 (9): 732–43. doi:10.1111/j.1365-2982.2007.00934.x. PMID 17727393. S2CID 11876042.
  4. Dawson LA, Cato KJ, Scott C, Watson JM, Wood MD, Foxton R, et al. (June 2008). "In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia". Neuropsychopharmacology. 33 (7): 1642–52. doi:10.1038/sj.npp.1301549. PMID 17728699.
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