Saredutant

Saredutant (SR-48,968) is a drug that acts as a NK2 receptor antagonist.[1] It was under development by Sanofi-Aventis as a novel antidepressant and anxiolytic and made it to phase III clinical trials. However, in May 2009, Sanofi-Aventis published its quarterly results and announced the cessation of 14 research/development projects, among which was saredutant for the treatment of major depressive disorder.[2]

Saredutant
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)- 2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.111.408
Chemical and physical data
FormulaC31H35Cl2N3O2
Molar mass552.54 g·mol−1
3D model (JSmol)
SMILES
  • Clc1ccc(cc1Cl)[C@H](CCN3CCC(c2ccccc2)(NC(=O)C)CC3)CN(C(=O)c4ccccc4)C
InChI
  • InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1 Y
  • Key:PGKXDIMONUAMFR-AREMUKBSSA-N Y
 NY (what is this?)  (verify)

See also

References
  1. Hopkins CR (October 2010). "ACS chemical neuroscience molecule spotlight on Saredutant". ACS Chemical Neuroscience. 1 (10): 653–4. doi:10.1021/cn100061r. PMC 3368631. PMID 22776916.
  2. "Letter to the stockholders of Sanofi-Aventis" (PDF). May 2009. Archived from the original (PDF) on 21 December 2010.


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