Tocofersolan

Tocofersolan
Names
IUPAC name
α-Hydro-ω-{[4-oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)butanoyl]oxy}poly(oxyethylene)
Other names
Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate (TPGS); Liqui-E
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.123.651
PubChem CID
UNII
InChI
  • InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3 Y
    Key: AOBORMOPSGHCAX-UHFFFAOYSA-N Y
  • InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
    Key: AOBORMOPSGHCAX-UHFFFAOYAU
SMILES
  • O=C(OCCO)CCC(=O)Oc2c(c(c1OC(CCc1c2C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)C
Properties
Chemical formula
 (C2H4O)nC33H54O5
Molar mass Variable
Pharmacology
A11HA08 (WHO)
License data
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references
Tocofersolan
Clinical data
Trade namesVedrop
Other namesTocophersolan (USAN US)
AHFS/Drugs.comUK Drug Information
Legal status
Legal status
  • UK: POM (Prescription only) [1]
  • EU: Rx-only [2]
Identifiers
DrugBank
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.123.651

Tocofersolan (INN) or tocophersolan, also referred to as TPGS (for tocopherol polyethylene glycol succinate), is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.[3] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients with congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).[4]

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.[5]

References
  1. "Vedrop 50 mg/ml oral solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Retrieved 24 July 2020.
  2. "Vedrop EPAR". European Medicines Agency (EMA). Retrieved 24 July 2020.
  3. "Tocophersolan Oral". WebMD.
  4. "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.
  5. Ash M, Ash I (2004). Handbook of Preservatives. p. 568. ISBN 1-890595-66-7.
  • "Tocophersolan". Drug Information Portal. U.S. National Library of Medicine.


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