Vi capsular polysaccharide vaccine

The Vi capsular polysaccharide vaccine (or ViCPS) is a typhoid vaccine recommended by the World Health Organization for the prevention of typhoid (another is Ty21a). The vaccine was first licensed in the US in 1994 and is made from the purified Vi capsular polysaccharide from the Ty2 Salmonella Typhi strain; it is a subunit vaccine.

Vi capsular polysaccharide vaccine
Vaccine description
TargetTyphoid
Vaccine typePolysaccharide
Clinical data
Trade namesTypherix, Typhim VI
AHFS/Drugs.comMultum Consumer Information
Routes of
administration		intramuscular injection, subcutaneous injection
ATC code
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
  • none
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Medical uses

The vaccine may be used in endemic areas in order to prevent typhoid. It is also commonly used to protect people who are traveling to parts of the world where typhoid is endemic.

Dosing

The vaccine is injected either under the skin or into a muscle at least seven days before traveling to the typhoid-affected area (the CDC recommend 14 days). The vaccine is not effective in children under the age of two.

To maintain immunity, the vaccine should be repeated every three years.

Efficacy and duration of protection

The vaccine offers effective protection the first year after being given (with between 50% and 80% efficacy) and the second year (31% to 76%), but not after that.[1]

Biology

The Vi polysaccharide, or Vi antigen, is part of the bacterial capsule found outside of the typhoid bacterium, Salmonella enterica subsp. enterica ser. Typhi. It is produced by the action of a single gene cluster in the cytoplasm and transported to the surface. This antigen contributes to much of typhoid's virulence, and is important for the infection of intestinal epithelial cells. It is also produced by S. enterica ser. Paratyphi C, the causative agent of paratyphoid fever C.[2]

Trade names

Research

A newer conjugate form of the vaccine (Vi bound to a non-toxic recombinant Pseudomonas aeruginosa exotoxin A, or Vi-rEPA) has enhanced efficacy,[3] including protection of children under 5 years of age.

The typhoid conjugate vaccine ("Typbar-TCV") is another Vi-based conjugate vaccine, in this case linked to Tetanus toxoid. It has been approved.[4]

See also

References
  1. Fraser A, Goldberg E, Acosta CJ, Paul M, Leibovici L (2007). Fraser A (ed.). "Vaccines for preventing typhoid fever". Cochrane Database Syst Rev (3): CD001261. doi:10.1002/14651858.CD001261.pub2. PMID 17636661.
  2. Hu, X; Chen, Z; Xiong, K; Wang, J; Rao, X; Cong, Y (August 2017). "Vi capsular polysaccharide: Synthesis, virulence, and application". Critical Reviews in Microbiology. 43 (4): 440–452. doi:10.1080/1040841X.2016.1249335. PMID 27869515. S2CID 205694206.
  3. Lin, FY; Ho, VA; Khiem, HB; Trach, DD; Bay, PV; Thanh, TC; Kossaczka, Z; Bryla, DA; Shiloach, J; Robbins, JB; Schneerson, R; Szu, SC (26 April 2001). "The efficacy of a Salmonella typhi Vi conjugate vaccine in two-to-five-year-old children". The New England Journal of Medicine. 344 (17): 1263–9. doi:10.1056/nejm200104263441701. PMID 11320385.
  4. "Typbar TCV Typhoid Vaccine". www.precisionvaccinations.com.



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