Baggio–Yoshinari syndrome

Baggio–Yoshinari syndrome
Other names: BYS, Brazilian Lyme-like disease, Brazilian human borreliosis
Amblyomma cajennense transmits the condition
SpecialtyInfectious disease

The Baggio–Yoshinari syndrome , formerly known as the Brazilian Lyme-like disease and Brazilian human borreliosis, is a disease transmitted by the Amblyomma cajennense tick, but the organism that causes the infection is still unknown.[1] Clinical features resemble those of Lyme disease (LD).[2]

Signs and symptoms

Individual with Baggio–Yoshinari syndrome

A distinct feature of the syndrome is its prolonged clinical evolution, with relapsing episodes and autoimmune dysfunction. If diagnosed in its early stages, the symptoms respond well to antibiotics. If the disease evolves to a chronic phase, it can potentially cause oligoarthritis, cognitive impairment, meningoencephalitis and erythema nodosum, with the patient risking to develop both articular and neurological sequelae.[2]

The neurological manifestations of BYS were first described by Yoshinari et al. including patients with peripheral neuritis, meningitis and cranial neuritis (facial nerve palsy, diplopia and deafness).[1]

Likely transmission vectors of BYS belong to the Amblyomma and Rhipicephalus genera, which could help to explain all the particularities observed in BYS versus LD.[1]

Some features of BYS also resemble those found in the Southern tick-associated rash illness (STARI, also known as Masters' disease), which is found in the Southern USA.[1]

Causes

The etiology of BYS is due to Borrelia burgdorferi sensu lato[3]

Diagnosis

In terms of the diagnosis of Baggio-Yoshinari syndrome one finds it is based on clinical and epidemiological data (and ruling out other possible conditions via DDx)[3]

Treatment

The management of Baggio-Yoshinari syndrome is done via:[3]

History

In 1989, Brazilian researchers Professors Domingos Baggio (an entomologist from the Biomedical Sciences Institute of the University of São Paulo), Paulo Yasuda (a microbiologist from the same institute) and Natalino Hajime Yoshinari (a physician from the Rheumatology Department at University of São Paulo's Medical School[1]) started research on Lyme disease in Brazil, by suggestion of Dr. Allen Steere. At that time, LD was almost unknown among Brazilian physicians.[4]

The first cases were described in Brazil in 1992 in siblings from Cotia, São Paulo that developed symptoms as a migrating redness, general flu-like symptoms and arthritis after being bitten by ticks. Although the symptoms were similar to those presented by patients of Lyme disease, clinical and laboratorial results were considerably different. Ticks of the Ixodes ricinus complex were not found at the risk areas; bacteria from the Borrelia burgdorferi sensu lato complex —that cause Lyme disease— were not found in biological fluids and tissues of the siblings.[5] Blood analysis of the patients on electron microscopy exhibited structures resembling microorganisms of the spirochaete phylum. For these reasons, the Brazilian zoonosis was considered a new disease and named Baggio–Yoshinari Syndrome (BYS), defined as: "Exotic and emerging Brazilian infectious disease, transmitted by ticks not belonging to the Ixodes ricinus complex, caused by latent spirochetes with atypical morphology, which originates LD-like symptoms, except for occurrence of relapsing episodes and auto-immune disorders".[5]

References

  1. 1 2 3 4 5 Revista Brasileira de Reumatologia, vol.49 no.5, São Paulo, Sept./Oct. 2009: Neurological manifestations in Baggio-Yoshinari Syndrome (Brazilian Lyme-like disease syndrome) Archived 2018-09-29 at the Wayback Machine
  2. 1 2 Revista Brasileira de Reumatologia, Vol.54, Issue 2, March–April 2014, Pages 148–151. Chronic lymphomonocytic meningoencephalitis, oligoarthritis and erythema nodosum: report of Baggio-Yoshinari syndrome of long and relapsing evolution Archived 2018-10-04 at the Wayback Machine
  3. 1 2 3 Yoshinari, Natalino Hajime; Bonoldi, Virginia Lucia Nazario; Bonin, Serena; Falkingham, Erica; Trevisan, Giusto (August 2022). "The Current State of Knowledge on Baggio–Yoshinari Syndrome (Brazilian Lyme Disease-like Illness): Chronological Presentation of Historical and Scientific Events Observed over the Last 30 Years". Pathogens. 11 (8): 889. doi:10.3390/pathogens11080889. Archived from the original on 7 September 2022. Retrieved 4 April 2023.
  4. ↑ Revista Brasileira de Pesquisas Médicas e Biológicas vol.40 no.4 Ribeirão Preto Apr. 2007: Description of Lyme disease-like syndrome in Brazil. Is it a new tick borne disease or Lyme disease variation? Archived 2021-02-26 at the Wayback Machine
  5. 1 2 Revista da Associação Médica Brasileira vol.56 no.3 São Paulo, 2010: Brazilian Lyme-like disease or Baggio-Yoshinari syndrome: exotic and emerging Brazilian tick-borne zoonosis Archived 2018-09-29 at the Wayback Machine
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