Fungal sinusitis

Fungal sinusitis
Aspergillus is responsible in 90% of cases of fungal sinusitis
SymptomsFacial pain[1]
TypesInvasive, Non-invasive[1]
Diagnostic methodCT scan, MRI[1]
TreatmentSurgical(Management depends on which type)[1]

Fungal sinusitis is the inflammation of the lining mucosa of the paranasal sinuses due to fungal infection, categorised according to whether it is localised ar spread into deep tissue.[2] It typically presents with facial pain.[1] Other symptoms include blocked nose, headache, dizziness, eye pain and swelling, behavioral changes, and recurrent vomiting.[2]

It occurs in people with reduced immunity. The maxillary sinus is the most commonly involved. Fungi responsible for fungal sinusitis are Aspergillus fumigatus (90%), Aspergillus flavus, and Aspergillus niger. Fungal sinusitis occurs most commonly in middle-aged populations. Diabetes mellitus is the most common risk factor involved.[3]

Types

Granuloma[4]

The types of fungal sinusitis are based on invasive and non-invasive as follows:[5][6]

  • Invasive
  • Non Invasive
  • Saprophytic infection
  • Sinus fungal ball
  • Eosinophil related FRS including AFRS

Difference between non-invasive, invasive and fulminant fungal sinusitis[7]

The type of fungal disease highly depends on the immunity of the patient. When a person has low immunity, they can get non-invasive fungal sinusitis, where the fungus will infect only the skin lining of the nasal and sinus cavity. When the immunity gets lowered, it will turn into invasive fungal sinusitis, and the infection can seep into the tissues making the infection dangerous. A person can have both non-invasive and invasive fungal sinusitis at the same time at different locations.[7]

Fulminant is the rarest and the most dangerous infection that can occur when immunity is too low. In this type of disease, the infection will not only seep into the tissues but also into blood vessels. Although it comes under invasive technically, when we say invasive fungal sinusitis we often refer to non-fulminant invasive fungal sinusitis as we can clearly distinguish both irrespective of the fact that symptoms are the same. The differentiating factor between invasive and fulminant infections is that the progress of the disease is very rapid in fulminant. The progress of the disease is so quick that it can kill a person in a month if not treated. One of the most common type of fulminant fungal infection is mucormycosis.[7]

Signs and symptoms

Individuals with the condition of fungal sinusitis mostly present with features that include facial pain and pain around the eyes, nasal congestion, rhinorrhea(running nose), headache, later there may be ophthalmoplegia (paralysis of ocular muscles).[1]

Pathophysiology

The mechanism of fungal sinusitis depends on which form, such as:

  • Acute fulminant form – the fungus invades into vessels causing thrombosis, necrosis with minimum inflammation [4]
  • Chronic invasive – fungal hyphae invades tissue leaving necrosis with minimal inflammation [4]
  • Granulomatous form – invasive hyphae invades tissue with inflammation and non-caseating granuloma (with foreign bodies).[4]
  • Saprophytic infection – growth of fungus seen on mucous crusts within sinus cavity.[4]
  • Sinus fungal ball – sequestration of fungal hyphae as densely tangled, and has gritty matted appearance.[4]
  • Eosinophil related Allergic fungal sinusitis – though not completely understood, a possible mechanism sees the protein component of fungus elicits IgE mediated allergic mucosal inflammation.[8]

Diagnosis

In terms of diagnosis, the clinical examination gives an idea about fungal sinusitis,[6] as well as:

MRI
  • Suggestive clinical features include - multiple recurrent episodes, persistent pathology, and absent ability to smell (the Eustachian tube may also be affected).[6]
  • X Ray - can be done if the diagnosis is not certain.[6]
  • CT – can document the presence of sinusitis, in the coronal views[1]
  • MRI – used to find the CNS spread (extent of the disease), to evaluate individuals who demonstrate signs of invasive fungal sinusitis [1]
  • Histology studies[1]

Treatment

Voriconazole

Treatment for fungal sinusitis can include surgical debridement; helps by slowing progression of disease thus allowing time for recovery[9] additionally we see the options below:

Epidemiology

Though it is widely held that fungal infections of the nose and paranasal sinuses are not common, most agree that their frequency has been increasing over past decades.[11]

See also

References

  1. 1 2 3 4 5 6 7 8 9 "Fungal Sinusitis: Background, History of the Procedure, Problem". eMedicine. 28 June 2016. Archived from the original on 17 April 2021. Retrieved 25 November 2016.
  2. 1 2 Akhondi, Hossein; Woldemariam, Bersabel; Rajasurya, Venkat (2022). "Fungal Sinusitis". StatPearls. StatPearls Publishing. Archived from the original on 2022-04-28. Retrieved 2022-04-27.
  3. ↑ P. Karthikeyan, V. Nirmal Coumare (October–December 2010). "Incidence and presentation of fungal sinusitis in patient diagnosed with chronic rhinosinusitis". Indian Journal of Otolaryngology Head and Neck Surgery. 62 (4): 381–5. doi:10.1007/s12070-010-0062-0. PMC 3266098. PMID 22319697.{{cite journal}}: CS1 maint: uses authors parameter (link)subscription needed
  4. 1 2 3 4 5 6 "Granulomatous Diseases of the Head and Neck: Overview, Autoimmune Granulomatous Diseases, Granulomatous Diseases of Unknown Etiology". eMedicine. 2018-08-24. Archived from the original on 2016-09-19. Retrieved 11 September 2016.
  5. ↑ Chakrabarti, Arunaloke; Denning, David W.; Ferguson, Berrylin J.; Ponikau, Jens; Buzina, Walter; Kita, Hirohito; Marple, Bradley; Panda, Naresh; Vlaminck, Stephan (2017-01-29). "Fungal Rhinosinusitis: A Categorization and Definitional Schema Addressing Current Controversies". The Laryngoscope. 119 (9): 1809–1818. doi:10.1002/lary.20520. ISSN 0023-852X. PMC 2741302. PMID 19544383.
  6. 1 2 3 4 "Sinusitis. Medical professional reference for Sinusitis. | Patient". Patient. Archived from the original on 2 February 2017. Retrieved 29 January 2017.
  7. 1 2 3 4 Meghanadh, Dr Koralla Raja (2022-03-26). "Invasive fungal sinusitis - diagnosis, treatment". Medy Blog. Archived from the original on 2022-04-28. Retrieved 2022-04-18.
  8. ↑ Glass, Daniel; Amedee, Ronald G. (1 January 2011). "Allergic Fungal Rhinosinusitis: A Review". The Ochsner Journal. 11 (3): 271–275. ISSN 1524-5012. PMC 3179194. PMID 21960761.
  9. ↑ Soler, Zachary M.; Schlosser, Rodney J. (1 January 2012). "The role of fungi in diseases of the nose and sinuses". American Journal of Rhinology & Allergy. 26 (5): 351–358. doi:10.2500/ajra.2012.26.3807. ISSN 1945-8924. PMC 3904040. PMID 23168148.
  10. ↑ Hupp, James R.; Ferneini, Elie M. (2016). Head, Neck and Orofacial Infections: An Interdisciplinary Approach E-Book. Elsevier Health Sciences. p. 45. ISBN 9780323289467. Archived from the original on 28 April 2022. Retrieved 4 March 2017.
  11. ↑ Karthikeyan, P.; Nirmal Coumare, V. (2017-01-29). "Incidence and Presentation of Fungal Sinusitis in Patient Diagnosed with Chronic Rhinosinusitis". Indian Journal of Otolaryngology and Head & Neck Surgery. 62 (4): 381–385. doi:10.1007/s12070-010-0062-0. ISSN 2231-3796. PMC 3266098. PMID 22319697.

Further reading

Classification
External resources
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