Intravenous sugar solution

Intravenous sugar solution
Chemical structure of dextrose
Names
Other namesDextrose solution, glucose solution
Clinical data
Main usesLow blood sugar[1]
Side effectsVein irritation, tissue damage[1]
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Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    use    		Intravenous
    Defined daily dosenot established[2]
    External links
    AHFS/Drugs.comMonograph
    Legal
    License data

    Intravenous sugar solution, also known as dextrose solution, is a mixture of dextrose (glucose) and water.[3] It is used to treat low blood sugar or water loss without electrolyte loss.[4] Water loss without electrolyte loss may occur in fever, hyperthyroidism, high blood calcium, or diabetes insipidus.[4] It is also used in the treatment of high blood potassium, diabetic ketoacidosis, and as part of parenteral nutrition.[4] It is given by injection into a vein.[4]

    Side effects may include irritation of the vein in which it is given, high blood sugar, and swelling.[4][5] Excess use may result in low blood sodium and other electrolyte problems.[4] Intravenous sugar solutions are in the crystalloid family of medications.[6] They come in a number of strengths including 5%, 10%, and 50% dextrose.[4] While they may start out hypertonic they become hypotonic solutions as the sugar is metabolised.[7] Versions are also available mixed with saline.[5]

    Dextrose solutions for medical use became available in the 1920s and 1930s.[8][9] It is on the World Health Organization's List of Essential Medicines.[10] The wholesale cost in the developing world is about US$1.00–1.80 per liter of 10% dextrose in water, and it is about US$0.60–2.40 per liter of 5% dextrose in normal saline.[11][12] In the United Kingdom a 50 ml vial of 50% solution costs the NHS 2.01 pounds.[4]

    Medical uses

    Administering a 5% sugar solution peri- and postoperatively usually achieves a good balance between starvation reactions and hyperglycemia caused by sympathetic activation. A 10% solution may be more appropriate when the stress response from the reaction has decreased, after approximately one day after surgery. After more than approximately 2 days, a more complete regimen of total parenteral nutrition is indicated.

    In people with high blood sodium and normal blood volumn, free water can be replaced using either 5% D/W or 0.45% saline.

    In people with fatty-acid metabolism disorder (FOD), 10% solution may be appropriate upon arrival to the emergency room.

    Dosage

    The defined daily dose is not established.[2] In adults the typical dose is 1 ml/kg by intravenous of a 50% glucose solution (also known as a 50% dextrose solution).[1] A second dose may be given in those whose blood sugar is still low after 15 minutes.[1] In children a 10% glucose solution should be used at a dose of 2 ml/kg by injection.[1] Children who are awake may be given a dose of 10 ml/kg of a 10% glucose solution by mouth.[13]

    Side effects

    Intravenous glucose is used in some Asian countries as a pick-me-up, for "energy", but is not part of routine medical care in the United States where glucose solution is a prescription drug. Asian immigrants to the United States are at risk of infection if they seek intravenous glucose treatment. It may be had at store-front clinics catering to Asian immigrants, despite having no more effect than drinking sugared water. The procedure is commonly called "ringer".[14]

    Concentrated dextrose solutions should not be administered subcutaneously or intramuscularly as they can cause cell death via dehydration and subsequent necrosis.

    Types

    Types of glucose/dextrose include:

    • D5W (5% dextrose in water), which consists of 278 mmol/L dextrose
    • D5NS (5% dextrose in normal saline), which, in addition, contains normal saline (0.9% w/v of NaCl).
      • D5 1/2NS 5% dextrose in half amount of normal saline (0.45% w/v of NaCl).[15]
    • D5LR (5% dextrose in lactated Ringer solution)
    • D50 – 50% dextrose in water

    The percentage is a mass percentage (or more precisely, a mass-volume percentage), so a 5% glucose/dextrose solution contains 50 g/L of glucose/dextrose (5g/100ml).

    Glucose provides energy 4 kcal/gram, so a 5% glucose solution provides 0.2 kcal/ml. If prepared from dextrose monohydrate, which provides 3.4 kcal/gram, a 5% solution provides 0.17 kcal/ml.[16]

    • Prefilled D50W syringe
      Prefilled D50W syringe
    • 5% glucose in water
      5% glucose in water

    References

    1. 1 2 3 4 5 "GLUCOSE 50% = DEXTROSE 50% injectable - Essential drugs". medicalguidelines.msf.org. Archived from the original on 28 August 2021. Retrieved 1 September 2020.
    2. 1 2 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 13 September 2020.
    3. ↑ "Dextrose". The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.
    4. 1 2 3 4 5 6 7 8 British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 683–684. ISBN 9780857111562.
    5. 1 2 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 491. hdl:10665/44053. ISBN 9789241547659.
    6. ↑ David, Suresh S. (2016). Clinical Pathways in Emergency Medicine. Springer. p. 62. ISBN 9788132227106. Archived from the original on 16 January 2017.
    7. ↑ Waldmann, Carl; Soni, Neil; Rhodes, Andrew (2008). Oxford Desk Reference: Critical Care. OUP Oxford. p. 142. ISBN 9780199229581. Archived from the original on 16 January 2017.
    8. ↑ Skipper, Annalynn (2012). Dietitian's Handbook of Enteral and Parenteral Nutrition. Jones & Bartlett Publishers. p. 283. ISBN 9780763742904. Archived from the original on 16 January 2017.
    9. ↑ Nelms, Marcia; Sucher, Kathryn (2015). Nutrition Therapy and Pathophysiology. Cengage Learning. p. 89. ISBN 9781305446007. Archived from the original on 16 January 2017.
    10. ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
    11. ↑ "Dextrose 10% in Water". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 8 December 2016.
    12. ↑ "Dextrose 5% in Sodium Chloride 0.9%". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 8 December 2016.
    13. ↑ "GLUCOSE 10% = DEXTROSE 10% - Essential drugs". medicalguidelines.msf.org. Archived from the original on 28 August 2021. Retrieved 4 September 2020.
    14. ↑ Jiha Ham (20 March 2015). "A Life Upended After an IV Glucose Treatment Popular Among Asian Immigrants". The New York Times. Archived from the original on 22 March 2015. Retrieved 21 March 2015. Although many doctors warn Asian immigrants in New York that the effects of injecting glucose differ little from drinking sugary water, many Asians, especially of older generations, still use the intravenous solution. In their homelands, it is commonly prescribed by doctors as a method to cure colds, fevers and sometimes an upset stomach.
    15. ↑ eMedicine > Hypernatremia: Treatment & Medication Archived 2011-03-02 at the Wayback Machine By Ivo Lukitsch and Trung Q Pham. Updated: Apr 19, 2010
    16. ↑ Calculating Parenteral Feedings Archived 2010-12-03 at the Wayback Machine D. Chen-Maynard at California State University, San Bernardino. Retrieved September 2010. HSCI 368
    Identifiers:
    • "Dextrose". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 17 December 2019. Retrieved 17 December 2019.
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