Acetyl-CoA hydrolase

The enzyme acetyl-CoA hydrolase (EC 3.1.2.1) catalyzes the reaction

acetyl-CoA + H2O CoA + acetate
acetyl-CoA hydrolase
Identifiers
EC no.3.1.2.1
CAS no.9027-54-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is CoA thiol esterase. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2H4U.

See also

References

    • Gergely J, Hele P, Ramakrishnan CV (1952). "Succinyl and acetyl coenzyme A deacylases". J. Biol. Chem. 198 (1): 323–334. PMID 12999747.


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