Chlorisondamine

Chlorisondamine
Clinical data
ATC code	None;
Identifiers
	IUPAC name Trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-isoindolin-2-ium-2-yl)ethyl]ammonium dichloride;
CAS Number	7701-62-4 ;
PubChem CID	6243;
ChemSpider	6008 ;
UNII	JD3M24F66I;
ChEMBL	ChEMBL2104531 ;
CompTox Dashboard (EPA)	DTXSID0048395 ;
Chemical and physical data
Formula	C14H20Cl6N2
Molar mass	429.03 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Cl-].[Cl-].Clc1c2c(c(Cl)c(Cl)c1Cl)C[N+](C2)(C)CC[N+](C)(C)C;
	InChI InChI=1S/C14H20Cl4N2/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15/h5-8H2,1-4H3/q+2 ; Key:IXWDUZLHWJKVPX-UHFFFAOYSA-N ;
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Chlorisondamine is a nicotinic acetylcholine receptor antagonist that produces both neuronal and ganglionic blockade.

Chlorisondamine has been shown to form noncovalent complexes with various biomolecules including sphingomyelin and other associated glycolipids.[1][2][3]

References

Woods AS, Moyer SC, Wang HY, Wise RA (2003). "Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor". Journal of Proteome Research. 2 (2): 207–12. doi:10.1021/pr025578h. PMID 12716135.
Jackson SN, Wang HY, Woods AS, Ugarov M, Egan T, Schultz JA (February 2005). "Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS". Journal of the American Society for Mass Spectrometry. 16 (2): 133–8. doi:10.1016/j.jasms.2004.10.002. PMID 15694763. S2CID 5894935.
Woods AS, Ugarov M, Egan T, Koomen J, Gillig KJ, Fuhrer K, Gonin M, Schultz JA (April 2004). "Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS". Analytical Chemistry. 76 (8): 2187–95. doi:10.1021/ac035376k. PMID 15080727.

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[pmid12716135-1] Woods AS, Moyer SC, Wang HY, Wise RA (2003). "Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor". Journal of Proteome Research. 2 (2): 207–12. doi:10.1021/pr025578h. PMID 12716135.

[pmid15694763-2] Jackson SN, Wang HY, Woods AS, Ugarov M, Egan T, Schultz JA (February 2005). "Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS". Journal of the American Society for Mass Spectrometry. 16 (2): 133–8. doi:10.1016/j.jasms.2004.10.002. PMID 15694763. S2CID 5894935.

[pmid15080727-3] Woods AS, Ugarov M, Egan T, Koomen J, Gillig KJ, Fuhrer K, Gonin M, Schultz JA (April 2004). "Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS". Analytical Chemistry. 76 (8): 2187–95. doi:10.1021/ac035376k. PMID 15080727.