Magnesium salicylate

Magnesium salicylate is a common analgesic[1] and nonsteroidal anti-inflammatory drug (NSAID)[2] used to treat mild to moderate musculoskeletal pain[3] such as in tendons and muscles. It is also used to treat joint pain like arthritis,[2][3] general back pain,[4] and headaches.

Magnesium salicylate
Identifiers
  • Magnesium(2+) bis(2-hydroxybenzoate)
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.038.775
Chemical and physical data
FormulaC14H10MgO6
Molar mass298.533 g·mol−1
3D model (JSmol)
  • [Mg++].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O
  • InChI=1S/2C7H6O3.Mg/c2*8-6-4-2-1-3-5(6)7(9)10;/h2*1-4,8H,(H,9,10);/q;;+2/p-2
  • Key:MQHWFIOJQSCFNM-UHFFFAOYSA-L

It is found in a variety of over-the-counter (OTC) medications, most notably the brand Doan's Pills, as an anti-inflammatory, primarily for back-pain relief. Magnesium salicylate can be an effective OTC alternative to prescription NSAIDs, with both anti-inflammatory and pain-relieving effects.[1]

Controversy

While magnesium salicylate is sold as an alternative for pain relief, it is still a nonsteroidal anti-inflammatory drug and, like others in this class, can cause stomach ulcers, [2] without any proven superiority to other over-the-counter pain relievers.

Novartis, the company (formerly known as Ciba or Ciba-Geigy Corp.) that produces Doan's Pills,[4] has claimed that the product is superior in providing back pain relief. In June 1996, the US Federal Trade Commission (FTC) charged the company with violating federal law with its unsubstantiated claim.[5][4] In March 1998, the court ruled in favor of the FTC, but there was no stipulation about how the company should or would have to amend its advertising/packaging. Thus, Doan's was able to continue marketing as a "superior treatment for back pain".[5] In May 1999, the FTC released a statement summarizing the proceedings and announced the commission's decision after a 4–0 vote imposing a penalty on Doan's and its marketer, Novartis, to "run ads to correct misbeliefs resulting from their unsubstantiated claim that Doan's Pills are superior to other over-the-counter analgesics for treating back pain" and to modify packaging to include the statement "Although Doan's is an effective pain reliever, there is no evidence that Doan's is more effective than other pain relievers for back pain."[4] The ads were required to run for a period of one year.[5]

References
  1. Terrie, Yvette C. (June 2013). "Pain Control: Using Nonprescription Analgesics". OTC Guide. 17 (1). Retrieved March 30, 2022 – via PharmacyTimes.com.
  2. "Magnesium Salicylate Tablet - Uses, Side Effects, and More". WebMD. WebMD LLC. Retrieved March 30, 2022.
  3. "Magnesium Salicylate tablets". clevelandclinic.org. Cleveland Clinic. Retrieved March 30, 2022.
  4. "Doan's boasts too big to swallow, FTC says". Tampa Bay Times (September 16, 2005 ed.). June 27, 1996. Retrieved March 30, 2022.
  5. "Doan's Pills Must Run Corrective Advertising: FTC Ads Claiming Doan's Is Superior In Treating Back Pain Were Unsubstantiated" (Press release). Federal Trade Commission. May 27, 1999. Retrieved March 30, 2022.
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