HLA-DR12
HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.
 | |
major histocompatibility complex, class II, DR12 | |
| Haplotypes groups | DQA*01:DRB1*1201 to DQA*01:DRB1*1203 DQA*01:DRB1*1206 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101 |
| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *1201 to *1203 *1206 |
| Symbol(s) | HLA-DRB1 |
| EBI-HLA | DRB1*1201 |
| EBI-HLA | DRB1*1202 Archived 2011-05-15 at the Wayback Machine |
| EBI-HLA | DRB1*1203 Archived 2011-05-15 at the Wayback Machine |
| EBI-HLA | DRB1*1306 |
| Shared data | |
| Locus | chr.6 6p21.31 |
Serology
| DRB1* | DR12 | DR5 | DR11 | Sample |
| allele | % | % | % | size (N) |
| 1201 | 83 | 4 | 2 | 893 [2] |
| 1202 | 89 | 162 | ||
| 1203 | >50 | 3 | ||
| 1206 | >50 | 2 | ||
The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215
Alleles
There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and particularly Indochina and the South Pacific.
Disease associations
DR12 is associated with vulval lichen sclerosus,[3] and undifferentiated spondyloarthritis.[4]
DRB1*1201 is associated with iritis in juvenile arthritis,[5] primary antiphospholipid syndrome,[6] tiopronin intolerance in rheumatoid arthritis,[7] adult chronic articular Still's disease[8]
DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population,[9] and narcolepsy in the Japanese population.
Extended linkage
DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease[10]
DRB1*1201:DRB3*01/03: colorectal cancer[11]
Genetic Linkage
DR12 Haplotypes | ||||
| Serotypes | DRA | DRB1 | DRB3 | |
|---|---|---|---|---|
| DR11(5)-DR52 | *0101 | *1201 | *0101 | |
| *0101 | *1202 | *0201 | ||
| *0101 | *1202 | *0202 | ||
| *0101 | *1202 | *0301 | ||
| Serotypes | DRB1 | DQA1 | DQB1 | |
| DR12(5)-DQ7 (7.5, 3) | *1201 | *0505 | *0301 | |
| *1202 | *0505 | *0301 | ||
| DR12(5)-DQ7 (7.3, 3) | *1201 | *0303 | *0301 | |
| DR12(5)-DQ7 (7.4, 3) | *1201 | *0401 | *0301 | |
| DR12(5)-DQ7 (7.6, 3) | *1201 | *0601 | *0301 | |
| Serotypes | HLA-A | HLA-C | HLA-B | DRB1 |
| A31(19)-Cw10-B51(5)-DR12(5) | *3101 | *0304 | *5101 | *1202 |
| A11-Cw9-B75(15)-DR12(5) | *1101 | *0303 | *1502 | *1202 |
| A2-Cw10-B13-DR12(5) | *0201 | *0304 | *1301 | *1202 |
HLA-DR12 is genetically linked to DR52[12] and HLA-DQ7 serotypes.
References
- derived from IMGT/HLA
- DR8 - 2%
- Gao X, Barnardo M, Winsey S, Ahmad T, Cook J, Agudelo J, Zhai N, Powell J, Fuggle S, Wojnarowska F (2005). "The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus". J Invest Dermatol. 125 (5): 895–9. doi:10.1111/j.0022-202X.2005.23905.x. PMID 16297186.
- Liao HT, Lin KC, Chen CH, et al. (2007). "Human Leukocyte Antigens in Undifferentiated Spondyloarthritis". Seminars in Arthritis and Rheumatism. 37 (3): 198–201. doi:10.1016/j.semarthrit.2007.04.004. PMID 17604825.
- Cerna M, Vavrincova P, Havelka S, Ivaskova E, Stastny P (1994). "Class II alleles in juvenile arthritis in Czech children". J Rheumatol. 21 (1): 159–64. PMID 8151573.
- Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients". Arthritis Rheum. 38 (9): 1340–1. doi:10.1002/art.1780380925. PMID 7575732.
- Ju LY, Paolozzi L, Delecoeuillerie G, et al. (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis". Clin. Exp. Rheumatol. 12 (3): 249–54. PMID 7915222.
- Fujii T, Nojima T, Yasuoka H, Satoh S, Nakamura K, Kuwana M, Suwa A, Hirakata M, Mimori T (2001). "Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease". Rheumatology (Oxford). 40 (12): 1398–404. doi:10.1093/rheumatology/40.12.1398. PMID 11752512.
- Himmunngan P, Sangwatanaroj S, Petmitr S, Viroonudomphol D, Siriyong P, Patmasiriwat P (2006). "HLa-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)". Southeast Asian J. Trop. Med. Public Health. 37 (2): 357–65. PMID 17124999.
- Tighe M, Hall M, Barbado M, Cardi E, Welsh K, Ciclitira P (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population". Tissue Antigens. 40 (2): 90–7. doi:10.1111/j.1399-0039.1992.tb01965.x. PMID 1357780.
- Bidwell J, Soong T, Raymond P, Doherty D, Hui K (1992). "HLA genotyping of colorectal carcinoma in the Chinese population". Hum Immunol. 34 (1): 19–23. doi:10.1016/0198-8859(92)90080-7. PMID 1356954.
- Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270–6. doi:10.1016/j.humimm.2003.12.005. PMID 15041167.