HLA-DR10
HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.
 | |
major histocompatibility complex, class II, DR10 | |
| Haplotypes groups | DQA*01:DRB1*1001 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101 |
| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *1001 |
| Symbol(s) | HLA-DRB1 |
| EBI-HLA | DRB1*1001 |
| Shared data | |
| Locus | chr.6 6p21.31 |
Serology
| DRB1* | DR10 | DR1 | Sample | |
| allele | % | % | % | size (N) |
| 1001 | 90 | 4 | 894 | |
The serological reaction of DR10 is relatively good.
Disease associations
By serotype
DR10 serotype or cognate alleles are associated with: Lichen planus[2]
By allele
DRB1*1001 is associated with ovarian cancer[3] and invasive squamous cell cervical cancer (SCC)[4]
Extended linkage
DRB1*1001:DQA1*01:DQB1*05 haplotype: Rheumatoid arthritis[5] The primary involvement appears to be DR10.
Genetic Linkage
DR10 Haplotypes | |||
| DRA | DRB1 | ||
|---|---|---|---|
| Haplotypes | *0101 | *1001 | |
| DQA1 | DQB1 | DRB1 | |
| Haplotypes | *0101 | *0501 | *1001 |
| HLA-A | HLA-B | DRB1 | |
| Haplotypes | *0000 | *0000 | *1001 |
HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5.
References
- derived from IMGT/HLA
- White A, Rostom A (1994). "HLA antigens in Arabs with lichen planus". Clinical and Experimental Dermatology. 19 (3): 236–7. doi:10.1111/j.1365-2230.1994.tb01174.x. PMID 8033385. S2CID 27001518.
- Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K (2006). "HLA-class II haplotype associations with ovarian cancer". Int J Cancer. 119 (12): 2980–5. doi:10.1002/ijc.22266. PMID 17016821.
- Madeleine M, Brumback B, Cushing-Haugen K, Schwartz S, Daling J, Smith A, Nelson J, Porter P, Shera K, McDougall J, Galloway D (2002). "Human leukocyte antigen class II and cervical cancer risk: a population-based study". J Infect Dis. 186 (11): 1565–74. doi:10.1086/345285. PMID 12447731.
- Pascual M, Nieto A, López-Nevot M, Ramal L, Matarán L, Caballero A, Alonso A, Martín J, Zanelli E (2001). "Rheumatoid arthritis in southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition". Arthritis Rheum. 44 (2): 307–14. doi:10.1002/1529-0131(200102)44:2<307::AID-ANR47>3.0.CO;2-K. PMID 11229460.
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