HLA-DR2

HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

Illustration of HLA-DR

Serology
DR15, DR2 and other serotype recognition of some DRB1*15 alleles[1]
DRB1*DR15 DR2DR16Sample
allele % % %size (N)
15:0176236428
15:027716676
15:038113286
15:04>501
15:05>252
15:07>501
.
DR16 DR2DR15N
16:01412919703
16:02473016239
16:04>501

Disease associations

DR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis,[2] and narcolepsy, tuberculoid leprosy[3] (multi-drug-resistant tuberculosis or leprosy),[4] ulcerative colitis(Japanese),[5] primary biliary cirrhosis and autoimmune hepatitis.[6] DR2 is also found in all patients that test positive for anti-anti-Asn-RNA-synthetase and chronic interstitial lung disease.[7]

Genetic linkage

DR2 is linked to the HLA-DR51.

References
  1. derived from IMGT/HLA
  2. Stewart G, McLeod J, Basten A, Bashir H (1981). "HLA family studies and multiple sclerosis: A common gene, dominantly expressed". Hum Immunol. 3 (1): 13–29. doi:10.1016/0198-8859(81)90040-9. PMID 7275697.
  3. van Eden W, de Vries R, Mehra N, Vaidya M, D'Amaro J, van Rood J (1980). "HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker". J Infect Dis. 141 (6): 693–701. doi:10.1093/infdis/141.6.693. PMID 6156220.
  4. Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK (2007). "Immunogenetics of mycobacterial infections in the North Indian population". Tissue Antigens. 69 Suppl 1: 228–30. doi:10.1111/j.1399-0039.2006.77311.x. PMID 17445206.
  5. Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S (1982). "Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis". Gastroenterology. 82 (3): 413–8. doi:10.1016/S0016-5085(82)80387-9. PMID 6947923.
  6. Miyamori H, Kato Y, Kobayashi K, Hattori N (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis". Digestion. 26 (4): 213–7. doi:10.1159/000198892. PMID 6409699.
  7. Hirakata M, Suwa A, Takada T, et al. (2007). "Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase". Arthritis Rheum. 56 (4): 1295–303. doi:10.1002/art.22506. PMID 17393393.
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