Nicotinyl alcohol

Nicotinyl alcohol (pyridylcarbinol) is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes flushing and may decrease blood pressure.[2]

Nicotinyl alcohol
Clinical data
Other namesRoniacol; Roniacol tartrate; Nicotinyl tartrate;[1] Nicotinyl alcohol tartrate; Nicotinic alcohol; Pyridylcarbinol
AHFS/Drugs.comMonograph
ATC code
Identifiers
  • (Pyridin-3-yl)methanol
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard100.002.604
Chemical and physical data
FormulaC6H7NO
Molar mass109.128 g·mol−1
3D model (JSmol)
  • OCc1cccnc1
  • InChI=1S/C6H7NO/c8-5-6-2-1-3-7-4-6/h1-4,8H,5H2 ☒N
 ☒NcheckY (what is this?)  (verify)

It appears as a crystal that dissolves in water and alcohol with ease, also soluble in ether; melting range 147–148 °C.

Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes cutaneous flushing in head and upper thorax with heat, but with no major effects in blood pressure. It is used in peripheral vascular diseases, like arteriosclerosis obliterans,[3] Raynaud's disease,[4] thromboangiitis obliterans (Buerger's disease),[5] arterial embolism, chilblains or migraine associated with vascular spasm.

Fischer and Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in symptoms related to intermittent claudication,[6] ulcer healing and others.[7]

Derivatives

At least a couple of uses for this agent were discovered over the years:

  1. Eniclobrate
  2. Mepiroxol
  3. Nicofibrate
  4. Pantenicate (Topanicate, MG 28362)

References
  1. Norwood WF (1963). "Vasodilator Effects of Nicotinyl Tartrate (Roniacol Tartrate)". JAMA. 186: 1013. doi:10.1001/jama.1963.03710110065012. PMID 14066712.
  2. "Ronicol Retard". Medical Dictionary Online. 2012. Archived from the original on June 14, 2011. Retrieved July 27, 2012.
  3. Richter IH, Fogel M, Fabricant H (1951). "An evaluation of roniacol tartrate in arteriosclerosis obliterans". New York State Journal of Medicine. 51 (10): 1303–4. PMID 14843421.
  4. "Medical Dictionary, Dictionary of medicine and human biology, medical, biological and chemical terminology". www.theodora.com.
  5. "Buergers disease by dr .ravinder narwal". July 7, 2011. page 18.
  6. Gillhespy, RO (1957). "Nicotinyl Alcohol Tartrate in Intermittent Claudication". British Medical Journal. 18 (2): 207–208. doi:10.1136/bmj.1.5012.207. PMC 1974214. PMID 13383231.
  7. Fisher MM, Tebrock HW (1953). "Nicotinic alcohol (roniacol) in peripheral vascular diseases and allied conditions: its use and limitations". New York State Journal of Medicine. 53 (1): 65–8. PMID 13025721.
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