Tolibut

Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) (that is, a GABA analogue) and is the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substitution. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia.[1][2][3][4]

Tolibut
Clinical data
ATC code
  • None
Identifiers
  • 4-Amino-3-(4-methylphenyl)butanoic acid
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC11H15NO2
Molar mass193.246 g·mol−1
3D model (JSmol)
  • CC1=CC=C(C=C1)C(CC(=O)O)CN
  • InChI=1S/C11H15NO2/c1-8-2-4-9(5-3-8)10(7-12)6-11(13)14/h2-5,10H,6-7,12H2,1H3,(H,13,14)
  • Key:MSZRPURXKHMSFF-UHFFFAOYSA-N

See also

References
  1. Tyurenkov IN, Borodkina LE, Bagmetova VV (September 2012). "Functional aspects of neuroprotective effects of new salts and compositions of baclofen in the convulsive syndrome caused by electroshock". Bulletin of Experimental Biology and Medicine. 153 (5): 710–713. doi:10.1007/s10517-012-1806-5. PMID 23113265. S2CID 767044.
  2. Morozov IS, Kovalev GI, Maisov NI, Kovalev GV, Raevskii KS (January 1977). "Effect of analogs of γ -aminobutyric acid on the uptake of [3H]-γ -aminobutyric acid by synaptosomes of the rat brain". Pharmaceutical Chemistry Journal. 11 (1): 10–12. doi:10.1007/BF00779108. S2CID 27281385.
  3. Dmitriev AV, Andreev NI (1987). "[The spectrum of analgesic activity of baclofen and tolibut]". Farmakologiia I Toksikologiia (in Russian). 50 (1): 24–27. PMID 3556547.
  4. Artem'ev II, Darinskiĭ I, Sologub MI (1992). "[A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level]". Eksperimental'naia i Klinicheskaia Farmakologiia (in Russian). 55 (1): 16–18. PMID 1363942.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.