Dyclonine

Dyclonine (Dyclocaine) is an oral anaesthetic that is the active ingredient of Sucrets, an over-the-counter throat lozenge.[1] It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.[2]

Dyclonine
Clinical data
Trade namesSucrets
AHFS/Drugs.comMonograph
Routes of
administration		Lozenge
ATC code
Legal status
Legal status
Identifiers
IUPAC name
  • 1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H27NO2
Molar mass289.419 g·mol−1
3D model (JSmol)
SMILES
  • O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2
InChI
  • InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3 Y
  • Key:BZEWSEKUUPWQDQ-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

History

The product Sucrets was introduced in Baltimore, Maryland, by Sharp & Dohme in 1932.[3]

In 1966 the Federal Trade Commission ordered Merck and Company to discontinue the false claims of germ-killing and pain-relieving properties for its Sucrets and Children's Sucrets throat lozenges.[4] In 1977, it was acquired by Beecham, later merging with SmithKline Beckman in 1989 to form SmithKline Beecham. By 1994 the brand switched from a metal container to a plastic container.[3] SmithKline Beecham, after announcing a merger with GlaxoWellcome to form GlaxoSmithKline, sold the brand in 2000 to Insight Pharmaceuticals. In 2011, Sucrets reintroduced their product back into the familiar tin due to popular demand and nostalgia.

See also

References
  1. Janice Jorgensen (1994). "Sucrets". Encyclopedia of Consumer Brands: Personal products. St. James Press. ISBN 9781558623378. Retrieved 2011-09-24.
  2. Gargiulo AV, Burns GM, Huck CP (1992). "Dyclonine hydrochloride--a topical agent for managing pain". Illinois Dental Journal. 61 (4): 303–4. PMID 1286862.
  3. "The Sucrets tin joins the age of plastics". USA Today. July 19, 1994. Retrieved 2011-09-24. Invented in Baltimore by Sharp & Dohme pharmaceutical in 1932, Sucrets have always been sold in the trademark metal box except for one 4⁄1-month period during the late 1960s when a tin shortage led to cardboard packaging, says [Frank Dzvonik].
  4. "F.T.C. Bids Merck Halt Claims That Lozenges Will Kill Germs". The New York Times. Associated Press. April 19, 1966. Retrieved 2011-09-24.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.