EGLU

EGLU ((2S)-α-ethylglutamic acid ) is a drug that is used in neuroscience research. It was one of the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and so has been useful in the characterization and study of this receptor subfamily.[1][2][3][4][5][6][7]

EGLU
Identifiers
IUPAC name
  • (2S)-2-Amino-2-ethylpentanedioic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC7H13NO4
Molar mass175.184 g·mol−1
3D model (JSmol)
SMILES
  • O=C(O)CC[C@](N)(C(=O)O)CC
InChI
  • InChI=1S/C7H13NO4/c1-2-7(8,6(11)12)4-3-5(9)10/h2-4,8H2,1H3,(H,9,10)(H,11,12)/t7-/m0/s1 N
  • Key:QFYBYZLHPIALCZ-ZETCQYMHSA-N N
 NY (what is this?)  (verify)

References
  1. Jane DE, Thomas NK, Tse HW, Watkins JC (1996). "Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord". Neuropharmacology. 35 (8): 1029–35. doi:10.1016/S0028-3908(96)00048-2. PMID 9121605. S2CID 6238847.
  2. Huang L, Rowan MJ, Anwyl R (February 1999). "Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro". European Journal of Pharmacology. 366 (2–3): 151–8. doi:10.1016/S0014-2999(98)00918-2. PMID 10082195.
  3. Palazzo E, Marabese I, de Novellis V, Oliva P, Rossi F, Berrino L, et al. (March 2001). "Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception". Neuropharmacology. 40 (3): 319–26. doi:10.1016/S0028-3908(00)00160-X. PMID 11166324. S2CID 41189905.
  4. Iserhot C, Gebhardt C, Schmitz D, Heinemann U (November 2004). "Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat". Brain Research. 1027 (1–2): 151–60. doi:10.1016/j.brainres.2004.08.052. PMID 15494166. S2CID 33373525.
  5. Cahusac PM, Wan H (April 2007). "Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo". Neuroscience. 146 (1): 202–12. doi:10.1016/j.neuroscience.2007.01.049. PMID 17346894. S2CID 37975672.
  6. Kim WY, Vezina P, Kim JH (August 2008). "Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment". Behavioural Brain Research. 191 (1): 62–6. doi:10.1016/j.bbr.2008.03.010. PMID 18433894. S2CID 24250755.
  7. Altinbilek B, Manahan-Vaughan D (January 2009). "A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory". Neuroscience. 158 (1): 149–58. doi:10.1016/j.neuroscience.2008.07.045. PMID 18722513. S2CID 40251815.
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