PCCG-4

PCCG-4 is a research drug which acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), with slight selectivity for mGluR2 although not sufficient to distinguish mGluR2 and mGluR3 responses from each other. It is used in research into the function of the group II metabotropic glutamate receptors.[1][2][3][4][5]

PCCG-4
Identifiers
IUPAC name
  • (2S,1'S,2'S,3'R)-2-(2'Carboxy-3'-phenylcyclopropyl)glycine
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
Chemical and physical data
FormulaC12H13NO4
Molar mass235.239 g·mol−1
3D model (JSmol)
SMILES
  • C1=CC=C(C=C1)[C@@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N
InChI
  • InChI=1S/C12H13NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h1-5,7-10H,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m1/s1 Y
  • Key:IFLWVSHRWAIVQF-KATARQTJSA-N Y
  (verify)

References
  1. Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C (May 1996). "Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist". Journal of Medicinal Chemistry. 39 (11): 2259–69. doi:10.1021/jm960059+. PMID 8667369.
  2. Thomsen C, Bruno V, Nicoletti F, Marinozzi M, Pellicciari R (July 1996). "(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors". Molecular Pharmacology. 50 (1): 6–9. PMID 8700119.
  3. Cozzi A, Attucci S, Peruginelli F, Marinozzi M, Luneia R, Pellicciari R, Moroni F (July 1997). "Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist". The European Journal of Neuroscience. 9 (7): 1350–5. doi:10.1111/j.1460-9568.1997.tb01489.x. PMID 9240392. S2CID 39993000.
  4. Ciccarelli R, Di Iorio P, Bruno V, Battaglia G, D'Alimonte I, D'Onofrio M, Nicoletti F, Caciagli F (September 1999). "Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes". Glia. 27 (3): 275–81. doi:10.1002/(SICI)1098-1136(199909)27:3<275::AID-GLIA9>3.0.CO;2-0. PMID 10457374.
  5. Vetter P, Garthwaite J, Batchelor AM (June 1999). "Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors". Neuropharmacology. 38 (6): 805–15. doi:10.1016/S0028-3908(99)00003-9. PMID 10465684. S2CID 10116115.


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