Gestational age

In obstetrics, gestational age is a measure of the age of a pregnancy which is taken from the beginning of the woman's last menstrual period (LMP),[1] or the corresponding age of the gestation as estimated by a more accurate method if available. Such methods include adding 14 days to a known duration since fertilization (as is possible in in vitro fertilization), or by obstetric ultrasonography. The popularity of using this definition of gestational age is that menstrual periods are essentially always noticed, while there is usually a lack of a convenient way to discern when fertilization occurred. Gestational age is contrasted with fertilization age which takes the date of fertilization as the start date of gestation.

For actual age of gestation, see embryonic age.

The initiation of pregnancy for the calculation of gestational age can differ from definitions of initiation of pregnancy in context of the abortion debate or beginning of human personhood.

Methods

According to American College of Obstetricians and Gynecologists, the main methods to calculate gestational age are:[2]

  • Directly calculating the days since the beginning of the last menstrual period
  • Early obstetric ultrasound, comparing the size of an embryo or fetus to that of a reference group of pregnancies of known gestational age (such as calculated from last menstrual periods) and using the mean gestational age of other embryos or fetuses of the same size. If the gestational age as calculated from an early ultrasound is contradictory to the one calculated directly from the last menstrual period, it is still the one from the early ultrasound that is used for the rest of the pregnancy.[2]
  • In case of in vitro fertilization, calculating days since oocyte retrieval or co-incubation and adding 14 days.[3]

Gestational age can also be estimated by calculating days from ovulation if it was estimated from related signs or ovulation tests, and adding 14 days by convention.[4]

A more complete listing of methods is given in following table:[5]

Method of estimating gestational ageVariability (2 standard deviations)[5]
Days from oocyte retrieval or co-incubation in in vitro fertilisation + 14 days±1 day
Days from estimated ovulation in Ovulation induction + 14 days±3 days
Days from artificial insemination + 14 days±3 days
Days from known single sexual intercourse + 14 days±3 days
Days from estimated ovulation by basal body temperature record + 14 days±4 days
First-trimester physical examination±2 weeks
Second-trimester physical examination±4 weeks
Third-trimester physical examination±6 weeks
First-trimester obstetric ultrasonography (crown-rump length)±8% of the estimate
Second-trimester obstetric ultrasonography (head circumference, femur length)±8% of the estimate
Third-trimester obstetric ultrasonography (head circumference, femur length)±8% of the estimate

As a general rule, the official gestational age should be based on the actual beginning of the last menstrual period, unless any of the above methods gives an estimated date that differs more than the variability for the method, in which case the difference cannot probably be explained by that variability alone.[5] For example, if there is a gestational age based on the beginning of the last menstrual period of 9.0 weeks, and a first-trimester obstetric ultrasonography gives an estimated gestational age of 10.0 weeks (with a 2 SD variability of ±8% of the estimate, thereby giving a variability of ±0.8 weeks), the difference of 1.0 weeks between the tests is larger than the 2 SD variability of the ultrasonography estimate, indicating that the gestational age estimated by ultrasonography should be used as the official gestational age.[5]

Once the estimated due date (EDD) is established, it should rarely be changed, as the determination of gestational age is most accurate earlier in the pregnancy.[6]

Following are diagrams for estimating gestational age from obstetric ultrasound, by various target parameters:

Comparison to fertilization age

The fertilization or conceptional age (also called embryonic age and later fetal age) is the time from the fertilization. It usually occurs within a day of ovulation, which, in turn, occurs on average 14.6 days after the beginning of the preceding menstruation (LMP).[7] There is also considerable variability in this interval, with a 95% prediction interval of the ovulation of 9 to 20 days after menstruation even for an average woman who has a mean LMP-to-ovulation time of 14.6.[8] In a reference group representing all women, the 95% prediction interval of the LMP-to-ovulation is 8.2 to 20.5 days.[7] The actual variability between gestational age as estimated from the beginning of the last menstrual period (without the use of any additional method mentioned in previous section) is substantially larger because of uncertainty which menstrual cycle gave rise to the pregnancy. For example, the menstruation may be scarce enough to give the false appearance that an earlier menstruation gave rise to the pregnancy, potentially giving an estimated gestational age that is approximately one month too large. Also, vaginal bleeding occurs during 15-25% of first trimester pregnancies,[9] and may be mistaken as menstruation, potentially giving an estimated gestational age that is too low.

Uses

Gestational age is used for example for:

Timeline of pregnancy by gestational age.

Estimation of due date
Distribution of gestational age at childbirth among singleton live births, given both when gestational age is estimated by first trimester ultrasound and directly by last menstrual period[10]
Main article: Estimated date of delivery

The mean pregnancy length has been estimated to be 283.4 days of gestational age as timed from the first day of the last menstrual period and 280.6 days when retrospectively estimated by obstetric ultrasound measurement of the fetal biparietal diameter (BPD) in the second trimester.[11] Other algorithms take into account other variables, such as whether this is the first or subsequent child, the mother's race, age, length of menstrual cycle, and menstrual regularity. In order to have a standard reference point, the normal pregnancy duration is assumed by medical professionals to be 280 days (or 40 weeks) of gestational age. Furthermore, actual childbirth has only a certain probability of occurring within the limits of the estimated due date. A study of singleton live births came to the result that childbirth has a standard deviation of 14 days when gestational age is estimated by first-trimester ultrasound and 16 days when estimated directly by last menstrual period.[10]

The most common system used among healthcare professionals is Naegele's rule, which estimates the expected date of delivery (EDD) by adding a year, subtracting three months, and adding seven days to the first day of a woman's last menstrual period (LMP) or corresponding date as estimated from other means.

Medical fetal viability

There is no sharp limit of development, gestational age, or weight at which a human fetus automatically becomes viable.[12] According to studies between 2003 and 2005, 20 to 35 percent of babies born at 23 weeks of gestation survive, while 50 to 70 percent of babies born at 24 to 25 weeks, and more than 90 percent born at 26 to 27 weeks, survive.[13] It is rare for a baby weighing less than 500 g (17.6 ounces) to survive.[12] A baby's chances for survival increases 3-4% per day between 23 and 24 weeks of gestation and about 2-3% per day between 24 and 26 weeks of gestation. After 26 weeks the rate of survival increases at a much slower rate because survival is high already.[14] Prognosis depends also on medical protocols on whether to resuscitate and aggressively treat a very premature newborn, or whether to provide only palliative care, in view of the high risk of severe disability of very preterm babies.[15]

Stages in prenatal development, showing viability and point of 50% chance of survival (limit of viability) at bottom. Weeks and months numbered by gestation,
Completed weeks of gestation at birth 21 and less2223242526273034
Chance of survival[14] <1%[16]0–10%10–35%40–70%50–80%80–90%>90%>95%>98%

Birth classification

Using gestational age, births can be classified into broad categories:

Gestational Age in WeeksClassification
< 37 0/7Preterm
34 0/7 - 36 6/7Late preterm[17]
37 0/7 - 38 6/7Early Term[18]
39 0/7 - 40 6/7Full Term[18]
41 0/7 - 41 6/7Late Term[18]
> 42 0/7Postterm

Using the LMP (last menstrual period) method, a full-term human pregnancy is considered to be 40 weeks (280 days), though pregnancy lengths between 38 and 42 weeks are considered normal. A fetus born prior to the 37th week of gestation is considered to be preterm. A preterm baby is likely to be premature and consequently faces increased risk of morbidity and mortality. An estimated due date is given by Naegele's rule.

According to the WHO, a preterm birth is defined as "babies born alive before 37 weeks of pregnancy are completed."[19] According to this classification, there are three sub-categories of preterm birth, based on gestational age: extremely preterm (fewer than 28 weeks), very preterm (28 to 32 weeks), moderate to late preterm (32 to 37 weeks).[19] Various jurisdictions may use different classifications.

In classifying perinatal deaths, stillbirths and infant deaths

For most of the 20th Century, official definitions of a live birth and infant death in the Soviet Union and Russia differed from common international standards, such as those established by the World Health Organization in the latter part of the century.[20][21] Babies who were fewer than 28 weeks of gestational age, or weighed fewer than 1000 grams, or fewer than 35 cm in length – even if they showed some sign of life (breathing, heartbeat, voluntary muscle movement) – were classified as "live fetuses" rather than "live births." Only if such newborns survived seven days (168 hours) were they then classified as live births. If, however, they died within that interval, they were classified as stillbirths. If they survived that interval but died within the first 365 days they were classified as infant deaths.

More recently, thresholds for "fetal death" continue to vary widely internationally, sometimes incorporating weight as well as gestational age. The gestational age for statistical recording of fetal deaths ranges from 16 weeks in Norway, to 20 weeks in the US and Australia, 24 weeks in the UK, and 26 weeks in Italy and Spain.[22][23][24]

The WHO defines the perinatal period as "The perinatal period commences at 22 completed weeks (154 days) of gestation and ends seven completed days after birth."[25] Perinatal mortality is the death of fetuses or neonates during the perinatal period. A 2013 study found that "While only a small proportion of births occur before 24 completed weeks of gestation (about 1 per 1000), survival is rare and most of them are either fetal deaths or live births followed by a neonatal death."[22]

Postnatal use

Gestational age (as well as fertilization age) is sometimes used postnatally (after birth) to estimate various risk factors. For example, it is a better predictor than postnatal age for risk of intraventricular hemorrhage in premature babies treated with extracorporeal membrane oxygenation.[26]

Factors affecting pregnancy length

Child's gestational age at birth (pregnancy length) is associated with various likely causal maternal non-genetic factors: stress during pregnancy,[27] age, parity, smoking, infection and inflammation, BMI. Also, preexisting maternal medical conditions with genetic component, e.g., diabetes mellitus type 1, systemic lupus erythematosus, anaemia. Parental ancestral background (race) also plays a role in pregnancy duration. Gestational age at birth is on average shortened by various pregnancy aspects: twin pregnancy, prelabor rupture of (fetal) membranes, pre-eclampsia, eclampsia, intrauterine growth restriction.[28] The ratio between fetal growth rate and uterine size (reflecting uterine distension) is suspected to partially determine the pregnancy length.[29]

Heritability of pregnancy length

Family-based studies showed that gestational age at birth is partially (from 25% to 40%) determined by genetic factors.[30]

See also

References
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  2. Obstetric Data Definitions Issues and Rationale for Change - Gestational Age & Term Archived 2013-11-06 at the Wayback Machine from Patient Safety and Quality Improvement at American Congress of Obstetricians and Gynecologists. Created November 2012.
  3. Tunon, K.; Eik-Nes, S. H.; Grøttum, P.; Von Düring, V.; Kahn, J. A. (2000). "Gestational age in pregnancies conceived after in vitro fertilization: A comparison between age assessed from oocyte retrieval, crown-rump length and biparietal diameter". Ultrasound in Obstetrics and Gynecology. 15 (1): 41–46. doi:10.1046/j.1469-0705.2000.00004.x. PMID 10776011. S2CID 20029116.
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