Immune disorder

An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.[5] There are at least 80 types of autoimmune diseases.[5] Nearly any body part can be involved. Common symptoms include low-grade fever and feeling tired.[5] Often symptoms come and go.[5]

Primary immune deficiency diseases are those caused by inherited genetic mutations. Secondary or acquired immune deficiencies are caused by something outside the body such as a virus or immune suppressing drugs.[6]

Primary immune diseases are at risk to an increased susceptibility to, and often recurrent ear infections, pneumonia, bronchitis, sinusitis or skin infections. Immunodeficient patients may less frequently develop abscesses of their internal organs, autoimmune or rheumatologic and gastrointestinal problems.[7]

Primary immune deficiencies

• Severe combined immunodeficiency (SCID)
• DiGeorge syndrome
• Hyperimmunoglobulin E syndrome (also known as Job's Syndrome)
• Common variable immunodeficiency (CVID): B cell levels are normal in circulation but with decreased production of IgG throughout the years, so it is the only primary immune disorder that presents onset in the late teens years.
• Chronic granulomatous disease (CGD): a deficiency in NADPH oxidase enzyme, which causes failure to generate oxygen radicals. Classical recurrent infection from catalase positive bacteria and fungi.
• Wiskott–Aldrich syndrome (WAS)
• Autoimmune lymphoproliferative syndrome (ALPS)
• Hyper IgM syndrome: X-linked disorder that causes a deficiency in the production of CD40 ligand on activated T cells. This increases the production and release of IgM into circulation. The B cell and T cell numbers are within normal limits. Increased susceptibility to extracellular bacteria and opportunistic infections.
• Leukocyte adhesion deficiency (LAD)
• NF-κB Essential Modifier (NEMO) Mutations
• Selective immunoglobulin A deficiency: the most common defect of the humoral immunity, characterized by a deficiency of IgA. Produces repeating sino-pulmonary and gastrointestinal infections.
• X-linked agammaglobulinemia (XLA; also known as Bruton type agammaglobulinemia): characterized by a deficiency in tyrosine kinase enzyme that blocks B cell maturation in the bone marrow. No B cells are produced to circulation and thus, there are no immunoglobulin classes, although there tends to be a normal cell-mediated immunity.
• X-linked lymphoproliferative disease (XLP)
• Ataxia–telangiectasia

Secondary immune deficiencies

• AIDS

An allergy is an abnormal immune reaction to a harmless antigen.

• Seasonal allergy
• Mastocytosis
• Perennial allergy
• Anaphylaxis
• Food allergy
• Allergic rhinitis[8]
• Atopic dermatitis

• Disorders of human immunity
• Hypersplenism

• Immune disorder at Curlie