Inositol nicotinate

Inositol nicotinate, also called inositol hexanicotinate, is marketed in the United States as a "no-flush niacin" dietary supplement.[1] Flushing, in physiology, essentially means that epidermal tissues have become reddened, such as when the skin is irritated from the histamine responses related to an allergic reaction, or from recent physical exercise, or even from anger or embarrassment. This form of niacin is supposed to reduce or prevent flushing by being broken down into the metabolites niacin (nicotinic acid) and inositol at a slow rate.[1]

Inositol nicotinate
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		oral
ATC code
Legal status
Legal status
Identifiers
IUPAC name
  • cyclohexane-1,2,3,4,5,6-hexayl hexanicotinate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.026.806
Chemical and physical data
FormulaC42H30N6O12
Molar mass810.732 g·mol−1
3D model (JSmol)
Melting point255 °C (491 °F)
SMILES
  • O=C(O[C@H]6[C@H](OC(=O)c1cccnc1)[C@H](OC(=O)c2cccnc2)[C@H](OC(=O)c3cccnc3)[C@@H](OC(=O)c4cccnc4)[C@@H]6OC(=O)c5cccnc5)c7cccnc7

See also
  • Esterification
  • Hydrolysis

References
  1. Taheri R (15 January 2003). "No-Flush Niacin for the Treatment of Hyperlipidemia". Medscape.com. Retrieved 14 September 2010.


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