Iopamidol

Iopamidol (INN), sold under the brand name Isovue among others, is a nonionic, low-osmolar iodinated contrast agent, developed by Bracco Diagnostics.

Iopamidol
Clinical data
Trade namesIsovue, Iopamiro, Gastromiro, others[1]
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		Intravascular, intravenous, intrathecal
ATC code
Legal status
Legal status
Identifiers
IUPAC name
  • 1-N,3-N-bis(1,3-dihydroxypropan-2-yl)-5-[(2S)-2-hydroxypropanamido]-2,4,6-triiodobenzene-1,3-dicarboxamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.056.430
Chemical and physical data
FormulaC17H22I3N3O8
Molar mass777.089 g·mol−1
3D model (JSmol)
SMILES
  • C[C@@H](C(=O)Nc1c(c(c(c(c1I)C(=O)NC(CO)CO)I)C(=O)NC(CO)CO)I)O
InChI
  • InChI=1S/C17H22I3N3O8/c1-6(28)15(29)23-14-12(19)9(16(30)21-7(2-24)3-25)11(18)10(13(14)20)17(31)22-8(4-26)5-27/h6-8,24-28H,2-5H2,1H3,(H,21,30)(H,22,31)(H,23,29)/t6-/m0/s1
  • Key:XQZXYNRDCRIARQ-LURJTMIESA-N
 NY (what is this?)  (verify)

It is available in various concentrations, from 200 to 370 mgI/mL.[4]

Medical uses

Iopamidol is indicated for angiography throughout the cardiovascular system, including cerebral and peripheral arteriography, coronary arteriography and ventriculography, pediatric angiocardiography, selective visceral arteriography and aortography, peripheral venography (phlebography), and adult and pediatric intravenous excretory urography and intravenous adult and pediatric contrast enhancement of computed tomographic (CECT) head and body imaging.[4]

It is also indicated for intrathecal administration in adult neuroradiology including myelography (lumbar, thoracic, cervical, total columnar), and for contrast enhancement of computed tomographic (CECT) cisternography and ventriculography. Isovue-M 200 (lopamidol Injection) is indicated for thoraco-lumbar myelography in children over the age of two years.[3]

As with other iodinated contrast agents there are concerns regarding safety, particularly relating to effects on renal function and allergic type reaction. Early generations of IV contrast carried considerable nephrotoxicity, necessitating continual assessment of renal function. IV and PO fluids are encouraged post operation to facilitate excretion of contrast. Shellfish allergies have previously thought to have crossover with iodine allergies with caution being advised with regards to the use of iodinated contrast in patients with shellfish, however shellfish have been demonstrated to be due to proteins produced by the organisms, not due to iodine.

References
  1. "Iopamidol". Drugs.com. 10 August 2020. Retrieved 14 August 2020.
  2. "Gastromiro - Summary of Product Characteristics (SmPC)". (emc). Retrieved 14 August 2020.
  3. "Isovue-M- iopamidol injection, solution". DailyMed. 24 October 2019. Retrieved 14 August 2020.
  4. "Isovue 300- iopamidol injection, solution Isovue 370- iopamidol injection, solution Isovue 200- iopamidol injection, solution Isovue 250- iopamidol injection, solution". DailyMed. 1 December 2019. Retrieved 14 August 2020.
  • "Iopamidol". Drug Information Portal. U.S. National Library of Medicine.


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