Metrizamide

Metrizamide is a non-ionic iodine-based radiocontrast agent.[1] It is also a density gradient medium for the centrifugation of biological particles.

Metrizamide
Clinical data
Trade namesAmipaque
Other names3-aAcetamido-2,4,6-triiodo-5-(N-methylacetamido)-N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]benzamide
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ATC code
Identifiers
IUPAC name
  • 2-({3-(Acetylamino)-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoyl}amino)-2-deoxy-D-glucopyranose
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.045.872
Chemical and physical data
FormulaC18H22I3N3O8
Molar mass789.100 g·mol−1
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Historically metrizamide replaced iofendylate (trade names: Pantopaque, Myodil) as the contrast agent of choice for myelography (an X-ray study of the spine now largely replaced by MRI). The radio opacity characteristics are such that finer detail is displayed with metrizamide, as well as the advantage of reabsorption from spinal fluid and excretion from the body – since unlike iofendylate, metrizamide is a water-soluble substance.

Both agents are administered by lumbar puncture (also referred to as a spinal tap or cisternal puncture), at the cervicocranial junction. The human patient is rolled from the lateral decubitus (lying on the side) to prone. Ankles are strapped to the end of a hard X-ray, CT, or MRI table. To obtain images of the cervical region the patient is then carefully tilted in the Trendelenberg position (head down) so the contrast agent (particularly iofendylate) can enter the neck region. Care is given to prevent spilling dye into the posterior cranial fossa (back of the head) or to enter the cranial cavity in general. This speaks to the inability to remove the heavier or more viscous iofendylate without aspirating it with spinal fluid through a lumbar puncture needle in the low back (sticking up vertically) or back of the neck. Removal of iofendylate is necessary since it is not water-soluble. With metrizamide the issue is that if entering the cranial cavity and high dose exposure to the blood brain barrier, side effects are more likely encountered. Issues related to absorption into the general circulation are also encountered.

Side effects

History

Metrizamide was approved in the US in 1978. Its marketing is discontinued as of 2021.[3]

References
  1. Hanus, P. M. (1980). "Metrizamide: a review with emphasis on drug interactions". American Journal of Hospital Pharmacy. 37 (4): 510–513. ISSN 0002-9289. PMID 6103672.
  2. Kassicieh et al. (1988), Conduction aphasia following metrizamide myelography, J Am Osteopath Assoc 1988 Vol. 88 Issue 3 Pages 384-6
  3. "Drugs@FDA: FDA-Approved Drugs: Amipaque". Food and Drug Administration. Retrieved 2021-03-31.

Further reading
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