MFZ 10-7

MFZ 10-7 (3-fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile) is a drug with potential applications in the treatment of addiction, which acts as a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Others of the kind, namely MPEP & MTEP, are not considered to have translational potential for human use due to off-target effects and short half-lives. Drugs of this kind have been used to offset craving for drugs of abuse such as cocaine in in vivo animal administration models.[1]

MFZ 10-7
Identifiers
IUPAC name
  • 3-fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile
CAS Number
ChemSpider
ChEMBL
Chemical and physical data
FormulaC15H9FN2
Molar mass236.244
3D model (JSmol)
SMILES
  • Cc1cccc(n1)C#Cc2cc(cc(c2)F)C#N
InChI
  • InChI=1S/C15H9FN2/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12/h2-4,7-9H,1H3
  • Key:ZGEXQIMQZVRTDZ-UHFFFAOYSA-N

See also

References
  1. Keck TM, Zou MF, Bi GH, Zhang HY, Wang XF, Yang HJ, et al. (March 2014). "A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats". Addiction Biology. 19 (2): 195–209. doi:10.1111/adb.12086. PMC 3942387. PMID 24001208.
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