Mericitabine

Mericitabine (RG-7128) is an antiviral drug, a deoxycytidine analog (a type of nucleoside analog). It was developed as a treatment for hepatitis C, acting as a NS5B RNA polymerase inhibitor, but while it showed a good safety profile in clinical trials, it was not sufficiently effective to be used as a stand-alone agent. However mericitabine has been shown to boost the efficacy of other antiviral drugs when used alongside them, and as most modern treatment regimens for hepatitis C use a combination therapy of several antiviral drugs, clinical trials have continued to see if it can form a part of a clinically useful drug treatment program.[1][2]

Mericitabine
Clinical data
Trade namesMericitabine
Legal status
Legal status
Identifiers
IUPAC name
  • [(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-fluoro-4-methyl-3-(2-methylpropanoyloxy)oxolan-2-yl]methyl 2-methylpropanoate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC18H26FN3O6
Molar mass399.419 g·mol−1
3D model (JSmol)
SMILES
  • CC(C)C(=O)OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=NC2=O)N)(C)F)OC(=O)C(C)C
InChI
  • InChI=1S/C18H26FN3O6/c1-9(2)14(23)26-8-11-13(28-15(24)10(3)4)18(5,19)16(27-11)22-7-6-12(20)21-17(22)25/h6-7,9-11,13,16H,8H2,1-5H3,(H2,20,21,25)/t11-,13-,16-,18-/m1/s1
  • Key:MLESJYFEMSJZLZ-MAAOGQSESA-N

See also

References
  1. Gentile I, Coppola N, Buonomo AR, Zappulo E, Borgia G (September 2014). "Investigational nucleoside and nucleotide polymerase inhibitors and their use in treating hepatitis C virus". Expert Opinion on Investigational Drugs. 23 (9): 1211–23. doi:10.1517/13543784.2014.921680. PMID 24848437. S2CID 12115460.
  2. Wedemeyer H, Forns X, Hézode C, Lee SS, Scalori A, Voulgari A, et al. (2016). "Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies". PLOS ONE. 11 (1): e0145409. Bibcode:2016PLoSO..1145409W. doi:10.1371/journal.pone.0145409. PMC 4713467. PMID 26752189.


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